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脂滴:大小至关重要。

Lipid droplets: size matters.

作者信息

Suzuki Michitaka, Shinohara Yuki, Ohsaki Yuki, Fujimoto Toyoshi

机构信息

Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

出版信息

J Electron Microsc (Tokyo). 2011;60 Suppl 1:S101-16. doi: 10.1093/jmicro/dfr016.

DOI:10.1093/jmicro/dfr016
PMID:21844583
Abstract

The lipid droplet (LD), an organelle that exists ubiquitously in various organisms, from bacteria to mammals, has attracted much attention from both medical and cell biology fields. The LD in white adipocytes is often treated as the prototype LD, but is rather a special example, considering that its size, intracellular localization and molecular composition are vastly different from those of non-adipocyte LDs. These differences confer distinct properties on adipocyte and non-adipocyte LDs. In this article, we address the current understanding of LDs by discussing the differences between adipocyte and non-adipocyte LDs.

摘要

脂滴(LD)是一种普遍存在于从细菌到哺乳动物等各种生物体中的细胞器,已引起医学和细胞生物学领域的广泛关注。白色脂肪细胞中的脂滴常被视为典型脂滴,但实际上它是一个特殊例子,因为其大小、细胞内定位和分子组成与非脂肪细胞脂滴有很大不同。这些差异赋予了脂肪细胞脂滴和非脂肪细胞脂滴不同的特性。在本文中,我们通过讨论脂肪细胞脂滴和非脂肪细胞脂滴之间的差异来阐述目前对脂滴的认识。

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