Centre de Recherche des Cordeliers, INSERM, U872, Paris F-75006, France.
Prog Lipid Res. 2009 May-Jul;48(3-4):191-5. doi: 10.1016/j.plipres.2009.03.001. Epub 2009 Mar 20.
In the recent years, new advances in the biology of lipid droplets led these structures specialized for lipid storage to be considered as new universal intracellular organelles playing active roles in cell physiology. Concomitantly, studies on the pathogenesis of metabolic diseases such as type 2 diabetes or atherosclerosis, associated with ongoing epidemic obesity, have pointed out the importance of lipotoxic effects in metabolic dysfunction, generated by ectopic lipid storage in non-adipose tissues. The purpose of this paper is to establish connections between recent discoveries in lipid droplet biology and novel views in the pathology of the metabolic syndrome. Bringing together the new concepts produced in these two separated fields might show the way towards the definition of innovative strategies to treat metabolic diseases. Particular attention is given to the role of adipocyte-specific proteins that interact with lipid droplets and confer unique functions to adipocyte lipid storage by limiting the spill-over of fatty acids and their lipotoxic effects.
近年来，脂滴生物学的新进展使得这些专门用于储存脂质的结构被认为是新的通用细胞内细胞器，在细胞生理学中发挥着积极的作用。与此同时，对代谢疾病（如与肥胖持续流行相关的 2 型糖尿病或动脉粥样硬化）发病机制的研究指出，在非脂肪组织中异位脂质储存产生的脂毒性效应对代谢功能障碍的重要性。本文旨在建立脂滴生物学的最新发现与代谢综合征病理学的新观点之间的联系。将这两个分离领域产生的新概念结合起来，可能会为制定治疗代谢疾病的创新策略指明方向。特别关注与脂滴相互作用的脂肪细胞特异性蛋白的作用，并通过限制脂肪酸的溢出及其脂毒性作用来赋予脂肪细胞脂质储存独特的功能。
