Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
Am J Med Sci. 2012 Feb;343(2):127-130. doi: 10.1097/MAJ.0b013e318223ac71.
Recently, there has been a surge of interest on the possible relationship between p53 polymorphism and coronary atherosclerosis. The authors have investigated the possible association of p53 codon 72 polymorphism with left ventricular ejection fraction (LVEF) in subjects with and without coronary artery disease (CAD).
The authors have studied 198 subjects admitted consecutively to Valmontone Hospital for CAD and 129 subjects admitted for cardiovascular diseases without CAD. Fifty-nine subjects admitted for CAD to Division of Cardiac Surgery of Tor Vergata University were also studied. All subjects were from the white population. The p53 polymorphism was evaluated using the restriction fragment length polymorphism polymerase chain reaction.
p53 codon 72 polymorphism is a significant independent predictor of LVEF in subjects with CAD but not in subjects with cardiovascular disease without CAD. In subjects with CAD, LVEF is significantly lower in subjects carrying the *Pro variant than in *Arg/*Arg subjects. This effect is more evident in subjects with a positive history of infarction.
Our study points to a significant relationship of p53 codon 72 polymorphism with cardiac function in subjects with CAD.
最近，人们对 p53 多态性与冠状动脉粥样硬化之间可能存在的关系产生了浓厚的兴趣。作者研究了 p53 密码子 72 多态性与冠心病（CAD）患者和非 CAD 患者左心室射血分数（LVEF）之间的可能相关性。
作者连续研究了 198 名因 CAD 入院的 Valmontone 医院患者和 129 名因心血管疾病而无 CAD 入院的患者。还研究了 59 名因 CAD 入院到 Tor Vergata 大学心脏外科系的患者。所有患者均来自白人人群。p53 多态性使用限制性片段长度多态性聚合酶链反应进行评估。
p53 密码子 72 多态性是 CAD 患者 LVEF 的独立显著预测因子，但对无 CAD 的心血管疾病患者则不是。在 CAD 患者中，携带Pro 变体的患者的 LVEF 明显低于Arg/*Arg 患者。这种影响在有梗塞阳性病史的患者中更为明显。
我们的研究表明，p53 密码子 72 多态性与 CAD 患者的心脏功能存在显著关系。
