Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy.
Med Sci Monit. 2012 Dec;18(12):CR712-5. doi: 10.12659/msm.883597.
Common biological features between cancer and atherosclerosis suggest possible association of p53 with atherosclerotic diseases, but data on such a relationship are controversial, suggesting interactions with other variables. Acid phosphatase locus 1 (ACPACP₁) is a polymorphic gene that controls the synthesis of an enzyme involved in important metabolic functions. Since ACPACP₁ is associated with coronary artery disease (CAD), we searched for possible interactions between this enzyme and p53 codon 72 polymorphism with regard to their effects on susceptibility to CAD.
MATERIAL/METHODS: The study included 381 patients admitted to the hospital for cardiovascular disease (232 patients with CAD and 149 with other cardiovascular problems) and 97 healthy newborns.
The proportion of subjects carrying the *Pro allele of p53 codon 72 and the high activity BC genotype of ACPACP₁ is higher in CAD (10.3%) than in non-CAD patients (2.0%) and in healthy newborns (6.2%).
The data suggest an interaction between p53 codon 72 and ACPACP₁ wherein a positive effect of the p53 *Pro allele on susceptibility to CAD occurs, but only in the presence of the ACPACP₁ genotype characterized by high enzymatic activity.
癌症和动脉粥样硬化之间存在共同的生物学特征，这表明 p53 可能与动脉粥样硬化疾病有关，但关于这种关系的数据存在争议，表明其与其他变量存在相互作用。酸性磷酸酶基因座 1（ACPACP₁）是一种多态性基因，控制着参与重要代谢功能的酶的合成。由于 ACPACP₁与冠心病（CAD）有关，我们搜索了这种酶与 p53 密码子 72 多态性之间可能存在的相互作用，以研究它们对 CAD 易感性的影响。
材料/方法：该研究纳入了 381 名因心血管疾病住院的患者（232 名 CAD 患者和 149 名其他心血管问题患者）和 97 名健康新生儿。
携带 p53 密码子 72 的Pro 等位基因和 ACPACP₁高活性B*C 基因型的受试者在 CAD 患者（10.3%）中的比例高于非 CAD 患者（2.0%）和健康新生儿（6.2%）。
数据表明 p53 密码子 72 与 ACPACP₁ 之间存在相互作用，其中 p53*Pro 等位基因对 CAD 的易感性有正向影响，但仅在 ACPACP₁ 基因型具有高酶活性的情况下才会发生。
