Institute of Pharmacology, College of Medicine, Kaohsiung Medical University, Taiwan.
Am J Gastroenterol. 2011 Dec;106(12):2098-103. doi: 10.1038/ajg.2011.277. Epub 2011 Aug 16.
Experimental studies have shown that statins have potential protective effects against cancer. The aim of this study was to investigate whether the use of statins was associated with gastric cancer risk.
We conducted a population-based case-control study in Taiwan. Data were retrospectively collected from the Taiwan National health Insurance Research Database. Cases consisted of all patients who were aged ≥50 years and had a first-time diagnosis of gastric cancer for the period between 2005 and 2008. The controls were matched to cases by age, sex, and index date. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by using multiple logistic regression.
We examined 337 gastric cancer cases and 1,348 controls. We found that ever-use of any statin was associated with a significant decrease in gastric cancer risk (OR=0.68, 95% CI=0.49-0.95). Compared with no use of statins, the adjusted ORs were 0.90 (95% CI=0.60-1.36) for the group having been prescribed statins with cumulative defined daily doses (DDDs) <134.25 and 0.49 (95% CI=0.30-0.79) for the group with cumulative statin use of ≥134.25 DDDs. Also, there was a significant trend toward decreasing gastric cancer risk with increasing cumulative dose (χ(2) for linear trend=7.42, P=0.006).
The results of this study are the first to suggest that statins may reduce the risk of gastric cancer.
实验研究表明，他汀类药物具有潜在的抗癌保护作用。本研究旨在探讨他汀类药物的使用与胃癌风险之间的关系。
我们在台湾进行了一项基于人群的病例对照研究。数据来自台湾全民健康保险研究数据库的回顾性收集。病例组由所有年龄≥50 岁且在 2005 年至 2008 年期间首次诊断为胃癌的患者组成。对照组与病例组按年龄、性别和索引日期相匹配。采用多因素 logistic 回归分析估计调整后的比值比（OR）和 95%置信区间（CI）。
我们共检查了 337 例胃癌病例和 1348 例对照。结果发现，使用任何他汀类药物与胃癌风险显著降低相关（OR=0.68，95%CI=0.49-0.95）。与未使用他汀类药物相比，累积定义日剂量（DDD）<134.25 的他汀类药物处方组的调整 OR 为 0.90（95%CI=0.60-1.36），累积他汀类药物使用量≥134.25 DDD 的组的调整 OR 为 0.49（95%CI=0.30-0.79）。此外，随着累积剂量的增加，胃癌风险呈显著下降趋势（线性趋势 χ²=7.42，P=0.006）。
本研究结果首次提示他汀类药物可能降低胃癌风险。
