Longman L P, Hibbert S A, Martin M V
School of Dental Surgery, University of Liverpool, United Kingdom.
Rev Infect Dis. 1990 Mar-Apr;12 Suppl 3:S294-8. doi: 10.1093/clinids/12.supplement_3.s294.
The efficacy of fluconazole, a bis-triazole antifungal agent, for prophylaxis and treatment of endocarditis due to Candida albicans and Candida parapsilosis is assessed in a rabbit model. Fourteen daily injections of fluconazole at doses of 20 and 10 mg/kg of body weight eradicated C. albicans and C. parapsilosis, respectively, from the cardiac vegetations in all animals tested. Amphotericin B (3 mg/kg) and flucytosine (35 mg/kg) both singly and in combination failed to achieve eradication in 100% of the animals. A two-dose prophylactic regimen of 30 mg of fluconazole/kg was consistently successful in preventing experimental endocarditis caused by C. albicans or C. parapsilosis.
在兔模型中评估了双三唑抗真菌剂氟康唑预防和治疗白色念珠菌和近平滑念珠菌引起的心内膜炎的疗效。每天分别以20毫克/千克和10毫克/千克体重的剂量注射14天氟康唑，可分别从所有受试动物的心脏赘生物中根除白色念珠菌和近平滑念珠菌。两性霉素B（3毫克/千克）和氟胞嘧啶（35毫克/千克）单独使用或联合使用均未能在100%的动物中实现根除。30毫克氟康唑/千克的两剂量预防方案始终成功预防了由白色念珠菌或近平滑念珠菌引起的实验性心内膜炎。
