Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SP, Brasil.
Braz J Med Biol Res. 2011 Oct;44(10):1006-12. doi: 10.1590/s0100-879x2011007500097. Epub 2011 Aug 12.
The association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most patients were males (87.6%). Subjects with 5 or more years of schooling had better survival in larynx cancer. Smoking had no effect on HNSCC survival, but alcohol consumption had a statistically significant effect on larynx cancer. IL-2 gene +114 G/T (HR = 0.52; 95%CI = 0.15-1.81) and T/T (HR = 0.22; 95%CI = 0.02-3.19) genotypes were associated with better survival in hypopharynx cancer. IL-2 +114 G/T was a predictor of poor survival in oral cavity/oropharynx cancer and larynx cancer (HR = 1.32; 95%CI = 0.61-2.85). IL-2 -384 G/T was associated with better survival in oral cavity/oropharynx cancer (HR = 0.80; 95%CI = 0.45-1.42) and hypopharynx cancer (HR = 0.68; 95%CI = 0.21-2.20), but an inverse relationship was observed for larynx cancer. IL-6 -174 G/C was associated with better survival in hypopharynx cancer (HR = 0.68; 95%CI = 0.26-1.78) and larynx cancer (HR = 0.93; 95%CI = 0.42-2.07), and C/C reduced mortality in larynx cancer. In general, our results are similar to previous reports on the value of education, smoking, alcohol consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of HNSCC, but the risks due to these variables are small and estimates imprecise.
该研究对 445 名患者进行了队列研究，以探讨教育、吸烟、饮酒以及白细胞介素-2（IL-2+114 和-384）和-6（IL-6-174）DNA 多态性与头颈部鳞状细胞癌（HNSCC）之间的关联。IL-2 和 IL-6 基因型通过实时 PCR 确定。根据头颈部解剖部位，Cox 回归用于估计疾病特异性生存率的危险比（HR）和 95%置信区间（95%CI）。平均年龄为 56 岁，大多数患者为男性（87.6%）。受教育时间为 5 年或以上的患者喉癌生存率更好。吸烟对 HNSCC 生存无影响，但饮酒对喉癌有统计学意义。IL-2 基因+114 G/T（HR=0.52；95%CI=0.15-1.81）和 T/T（HR=0.22；95%CI=0.02-3.19）基因型与下咽癌生存相关。IL-2+114 G/T 是口腔/口咽癌和喉癌不良预后的预测因子（HR=1.32；95%CI=0.61-2.85）。IL-2-384 G/T 与口腔/口咽癌（HR=0.80；95%CI=0.45-1.42）和下咽癌（HR=0.68；95%CI=0.21-2.20）的生存相关，而与喉癌呈负相关。IL-6-174 G/C 与下咽癌（HR=0.68；95%CI=0.26-1.78）和喉癌（HR=0.93；95%CI=0.42-2.07）的生存相关，而 C/C 降低了喉癌的死亡率。总体而言，我们的结果与之前关于教育、吸烟、饮酒以及 IL-2 和 IL-6 遗传多态性对 HNSCC 预后价值的报道相似，但这些变量的风险较小，估计结果也不精确。
