Clinical Research Institution, First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, People's Republic of China.
Cell Tissue Res. 2012 Jan;347(1):73-84. doi: 10.1007/s00441-011-1225-3. Epub 2011 Aug 16.
Transforming growth factor-β (TGF-β) is a ubiquitous cytokine playing an essential role in cell proliferation, differentiation, apoptosis, adhesion and invasion, as well as in cellular microenvironment. In malignant diseases, TGF-β signaling features a growth inhibitory effect at an early stage but aggressive oncogenic activity at the advanced malignant state. Here, we update the current understanding of TGF-β signaling in cancer development and progression with a focus on breast cancer. We also review the current approaches of TGF-β signaling-targeted therapeutics for human malignancies.
转化生长因子-β（TGF-β）是一种普遍存在的细胞因子，在细胞增殖、分化、凋亡、黏附和侵袭以及细胞微环境中发挥着重要作用。在恶性疾病中，TGF-β信号在早期表现出生长抑制作用，但在晚期恶性状态下则表现出侵袭性致癌活性。在这里，我们更新了目前对 TGF-β信号在癌症发展和进展中的理解，重点关注乳腺癌。我们还回顾了目前针对人类恶性肿瘤的 TGF-β信号靶向治疗方法。
