Talar Beata, Czyż Małgorzata
Zakład Biologii Molekularnej Nowotworów, Uniwersytet Medyczny w Łodzi.
Postepy Hig Med Dosw (Online). 2013 Sep 25;67:1008-17. doi: 10.5604/17322693.1068073.
TGF-β is a multifunctional cytokine involved in growth, cell differentiation and maintenanceof tissue homeostasis. In addition, TGF-β plays a key role in the pathogenesis of many diseases, including cancer. TGF-β-induced signaling pathways have either tumor-suppression or tumor-promoting effects in a cancer-type-specific and stage-dependent manner. TGF-β at an early stage of cancer development induces signaling pathways involved in inhibitionof cell proliferation, induction of differentiation, apoptosis or autophagy, suppression of angiogenesis and inflammation. At a later stage of disease, TGF-β exerts metastasis-promoting activity associated with epithelial-to-mesenchymal transition, modulation of cancer microenvironment and extracellular matrix components, inflammation and immune suppression. Furthermore, the TGF-β pathways play a pivotal role in the maintenance of stem cell-like properties of tumor cells. The pleiotropic action of TGF-β during tumorigenesis depends on interactions with different signaling pathways, including Hedgehog, WNT, PI3K--AKT, NOTCH, INF-γ, TNF-α, and RAS-ERK.
转化生长因子-β（TGF-β）是一种多功能细胞因子，参与生长、细胞分化以及组织稳态的维持。此外，TGF-β在包括癌症在内的多种疾病的发病机制中起关键作用。TGF-β诱导的信号通路在癌症类型特异性和阶段依赖性方面具有抑癌或促癌作用。在癌症发展的早期阶段，TGF-β诱导参与抑制细胞增殖、诱导分化、凋亡或自噬、抑制血管生成和炎症的信号通路。在疾病的后期阶段，TGF-β发挥促进转移的活性，这与上皮-间质转化、癌症微环境和细胞外基质成分的调节、炎症和免疫抑制有关。此外，TGF-β信号通路在维持肿瘤细胞的干细胞样特性中起关键作用。TGF-β在肿瘤发生过程中的多效作用取决于与不同信号通路的相互作用，包括刺猬信号通路（Hedgehog）、WNT信号通路、PI3K-AKT信号通路、NOTCH信号通路、INF-γ、TNF-α和RAS-ERK信号通路。
