Institute of Brain Science, Medical School, Shanxi Datong University, P.R.China.
Folia Neuropathol. 2011;49(2):78-87.
Cerebral hypoxic-ischaemic injury is involved in many central nervous system diseases. The mechanisms of neuron injury and death in cerebral hypoxic ischaemia remain unclear. There have been many theories on pathogenesis of neuron injury and death in cerebral hypoxic ischaemia, such as the toxicity of excitatory amino acid, NO, the production of oxygen free radicals, chondriosome injury, complement component, injury of immunological inflammation, matrix metalloproteinase, dopamine, Ca2+ overloading, cell apoptosis and so on. The aim of this review is to describe recent observations regarding the mechanisms of neuron injury and death in cerebral hypoxic ischaemia.
脑缺氧缺血损伤涉及许多中枢神经系统疾病。脑缺氧缺血时神经元损伤和死亡的机制尚不清楚。关于脑缺氧缺血时神经元损伤和死亡的发病机制有许多理论，如兴奋性氨基酸的毒性、NO、氧自由基的产生、线粒体损伤、补体成分、免疫炎症损伤、基质金属蛋白酶、多巴胺、Ca2+超载、细胞凋亡等。本文旨在描述脑缺氧缺血时神经元损伤和死亡机制的最新观察结果。
