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新生仔猪缺氧缺血后基底节区谷氨酸代谢和灌注的早期变化：一项多序列3.0T磁共振研究

Early Changes in Glutamate Metabolism and Perfusion in Basal Ganglia following Hypoxia-Ischemia in Neonatal Piglets: A Multi-Sequence 3.0T MR Study.

作者信息

Dang Yu-Xue, Shi Kai-Ning, Wang Xiao-Ming

机构信息

Department of Radiology, Shengjing Hospital of China Medical UniversityShenyang, China.

Department of Imaging Systems Clinical Science, Philips HealthcareBeijing, China.

出版信息

Front Physiol. 2017 Apr 25;8:237. doi: 10.3389/fphys.2017.00237. eCollection 2017.

DOI:10.3389/fphys.2017.00237
PMID:28487658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5404207/
Abstract

The excitotoxicity of glutamate metabolism as well as hemodynamic disorders of the brain are both risk factors for neonatal hypoxic-ischemic brain damage (HIBD). In the present study, changes in glutamate metabolism in the basal ganglia were detected by proton magnetic resonance spectroscopy (H-MRS) at 0-6, 8-12, 24-30, and 48-60 h after the induction of hypoxia-ischemia (HI) in newborn piglets. Meanwhile, correlation analysis was performed by combining the microcirculatory perfusion informations acquired by intravoxel incoherent motion (IVIM) scan to explore their possible interaction mechanism. The results suggested that Glu level in the basal ganglia underwent a "two-phase" change after HI; perfusion fraction , an IVIM-derived perfusion parameter, was clearly decreased in the early stage after HI, then demonstrated a transient and slight recovery process, and thereafter continued to decrease. The changes in and Glu level were in a significant negative correlation ( = -0.643, = 0.001). Our study results revealed that Glu level is closely associated with the microcirculatory perfusion changes in the acute stage of HIBD.

摘要

谷氨酸代谢的兴奋性毒性以及脑血流动力学紊乱均是新生儿缺氧缺血性脑损伤（HIBD）的危险因素。在本研究中，通过质子磁共振波谱（H-MRS）检测新生仔猪缺氧缺血（HI）诱导后0 - 6、8 - 12、24 - 30和48 - 60小时基底神经节中谷氨酸代谢的变化。同时，结合体素内不相干运动（IVIM）扫描获取的微循环灌注信息进行相关性分析，以探讨其可能的相互作用机制。结果表明，HI后基底神经节中的Glu水平经历了“两阶段”变化；IVIM衍生的灌注参数灌注分数在HI后的早期明显降低，随后呈现短暂且轻微的恢复过程，此后继续降低。 与Glu水平的变化呈显著负相关（ = -0.643， = 0.001）。我们的研究结果表明，Glu水平与HIBD急性期的微循环灌注变化密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600c/5404207/f9b2015b3f07/fphys-08-00237-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600c/5404207/793c3396bac1/fphys-08-00237-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600c/5404207/be8dea314007/fphys-08-00237-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600c/5404207/a30aee0f17e7/fphys-08-00237-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600c/5404207/4c5ebca34550/fphys-08-00237-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600c/5404207/33aef098b7f9/fphys-08-00237-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600c/5404207/f9b2015b3f07/fphys-08-00237-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600c/5404207/793c3396bac1/fphys-08-00237-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600c/5404207/be8dea314007/fphys-08-00237-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600c/5404207/a30aee0f17e7/fphys-08-00237-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600c/5404207/4c5ebca34550/fphys-08-00237-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600c/5404207/33aef098b7f9/fphys-08-00237-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/600c/5404207/f9b2015b3f07/fphys-08-00237-g0006.jpg

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