Institute of Clinical Pharmacology and Toxicology, Prishtina University, Republic of Kosova.
Folia Neuropathol. 2011;49(2):115-22.
Neuronal and axonal degenerative changes in motor vagal neurons (DMNV) and sensory vagal neurons (nTS) in the medulla oblongata in newborns were studied. Material was taken from the autopsies of newborns, live and dead newborns, in different gestational weeks (aborted, immature, premature and mature). 46 cases were studied. Material for research was taken from the medulla oblongata and lung tissue. Serial horizontal incisions were made in the medulla oblongata (± 4 mm), commencing from the obex, where the DMNV and nTS vagal nuclei were explored. Fixed cuttings in buffered formalin (10%) were used for histochemical staining. Serial cuttings were done with a microtome (7 µm). Pulmonary infections, being significant (p < 0.05), have an important place when studying respiratory distress (RD) in newborns. Morphological changes of nerve cells in DMNV and nTS nuclei in the medulla oblongata in newborns in different gestational weeks are more emphasized in matures in comparison to aborted and immature (p < 0.05). Depending on the lifetime of dead newborns, neuronal morphological changes in vagus nerve nuclei are significant (p < 0.05). Therefore, it can be concluded that pulmonary infections are often caused due to dramatic respiratory distress in newborns, while hypoxaemic changes in the population of vagus nerve neurons in respiratory distress are more emphasized in matures.
研究了延髓中运动迷走神经神经元 (DMNV) 和感觉迷走神经神经元 (nTS) 的神经元和轴突退行性变化。材料取自不同胎龄（流产、未成熟、早产和成熟）的新生儿、活产和死产新生儿的尸检。研究了 46 例病例。研究材料取自延髓和肺组织。在延髓中进行了水平切片（± 4 毫米），从舌咽神经和迷走神经核所在的枕骨开始。使用缓冲福尔马林（10%）固定切片进行组织化学染色。用切片机（7 微米）进行连续切片。肺部感染（p < 0.05）在研究新生儿呼吸窘迫（RD）时具有重要意义。与流产和未成熟相比，在成熟的新生儿中，DMNV 和 nTS 核中神经细胞的形态变化在不同胎龄的延髓中更为明显（p < 0.05）。根据新生儿死亡时间的不同，迷走神经核中神经元的形态变化具有统计学意义（p < 0.05）。因此，可以得出结论，肺部感染通常是由于新生儿呼吸窘迫引起的，而在呼吸窘迫的迷走神经神经元中，低氧血症变化在成熟人群中更为明显。
