Takashima S, Becker L E
Exp Neurol. 1985 Dec;90(3):580-7. doi: 10.1016/0014-4886(85)90155-4.
Dendritic development and gliosis in the medullary magnocellular reticular nucleus and solitary and dorsal vagal nuclei of 15 cases with sudden infant death syndrome (SIDS) and 23 control subjects were compared using morphometric Golgi and immunohistochemical methods. Developmental delay of the normal diminution of dendritic spines was found in the magnocellular reticular nucleus and/or vagal nuclei of 50 to 80% of SIDS infants. Astrocytes reactive with antisera to glial fibrillary acidic protein also increased in those regions, although dendritic spine density was inconsistent with the presence of astrogliosis in 20 to 40% of the cases. This delayed neuronal maturation of dendritic spines suggests there are immature neural respiratory control mechanisms in SIDS.
运用形态计量学高尔基法和免疫组化方法，比较了15例婴儿猝死综合征（SIDS）病例和23例对照受试者延髓大细胞网状核、孤束核及迷走神经背核中的树突发育和胶质细胞增生情况。发现50%至80%的SIDS婴儿的大细胞网状核和/或迷走神经核中，正常情况下树突棘减少过程出现发育延迟。尽管在20%至40%的病例中树突棘密度与星形胶质细胞增生情况不一致，但那些区域中对胶质纤维酸性蛋白抗血清呈反应性的星形胶质细胞也增多。树突棘这种神经元成熟延迟表明SIDS中存在不成熟的神经呼吸控制机制。
