Arkin Abdureyim, Arzguli Kyrm, Cheng Xiuqin
Department of Otorhinolaryngology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Jun;25(11):482-5.
To compare the bacteriologic features of anterior ethmoidal biopsy specimens between chronic rhinosinusitis without nasal polyps (CRSNP-), chronic rhinosinusitis with nasal polyps(CRSNP+) and control patients.
The biopsy specimens obtained during the nasal endoscopic surgery were cultured for aerobic and anaerobic bacteria.
One hundred and nineteen biopsy specimens were processed for homogenization and semiquantitatively bacterial culture of aerobe and anaerobe. Bacterial culture were positive in 104 specimens (total culture-positive rate was 87.4%). The positive rate of aerobe or facultative anaerobe culture were 86.5%, 85.7%, 90.0% in CRSNP- group, CRSNP+ group and control group, respectively. There were no significant differences between 3 groups (P > 0.05). Mixed growth of aerobe and anaerobe bacteria were mainly detected in the biopsy specimens and the positive rate were 78.4%, 81.0% and 85.0% in CRSNP- group, CRSNP+ group and control group. There were no significant differences in 3 groups (P > 0.05). The most common aerobe bacteria found in 3 groups were coagulase-negative staphylococci and corynebacterium species and there were no significant differences between 3 groups (P > 0.05). The positive rate of anaerobic bacteria culture were 78.4%,76.2% and 77.5% in 3 groups. There were no significant differences between the groups (P > 0.05). Propionibacterium and peptostreptococcus species were the most common anaerobes, and there were no significant differences between 3 groups (P > 0.05).
There are no significant differences in the bacteriologic features of ethmoidal biopsy specimens between CRSNP+, CRSNP- and control patients. Therefore, bacterial infection may not play a key role in the pathogenesis of nasal polyps in CRS patients.
比较无鼻息肉慢性鼻-鼻窦炎（CRSNP-）、有鼻息肉慢性鼻-鼻窦炎（CRSNP+）患者及对照患者筛前活检标本的细菌学特征。
对鼻内镜手术中获取的活检标本进行需氧菌和厌氧菌培养。
119份活检标本进行了匀浆处理及需氧菌和厌氧菌的半定量细菌培养。104份标本细菌培养阳性（总培养阳性率为87.4%）。CRSNP-组、CRSNP+组和对照组需氧菌或兼性厌氧菌培养阳性率分别为86.5%、85.7%、90.0%，三组间差异无统计学意义（P>0.05）。活检标本中主要检测到需氧菌和厌氧菌混合生长，CRSNP-组、CRSNP+组和对照组阳性率分别为78.4%、81.0%和85.0%，三组间差异无统计学意义（P>0.05）。三组中最常见的需氧菌是凝固酶阴性葡萄球菌和棒状杆菌属，三组间差异无统计学意义（P>0.05）。三组厌氧菌培养阳性率分别为78.4%、76.2%和77.5%，组间差异无统计学意义（P>0.05）。丙酸杆菌属和消化链球菌属是最常见的厌氧菌，三组间差异无统计学意义（P>0.05）。
CRSNP+组、CRSNP-组患者及对照患者筛窦活检标本的细菌学特征无显著差异。因此，细菌感染可能在CRS患者鼻息肉发病机制中不起关键作用。
