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双胞胎数据的社会科学方法:整合因果关系、禀赋和遗传力。

Social science methods for twins data: integrating causality, endowments, and heritability.

作者信息

Kohler Hans-Peter, Behrman Jere R, Schnittker Jason

机构信息

Department of Sociology and Population Studies Center, University of Pennsylvania, Philadelphia, PA 19104-6299, USA.

出版信息

Biodemography Soc Biol. 2011;57(1):88-141. doi: 10.1080/19485565.2011.580619.

Abstract

Twins have been extensively used in economics, sociology, and behavioral genetics to investigate the role of genetic endowments on a broad range of social, demographic, and economic outcomes. However, the focus in these literatures has been distinct.: The economic literature has been primarily concerned with the need to control for unobserved endowments--including as an important subset, genetic endowments--in analyses that attempt to establish the impact of one variable, often schooling, on a variety of economic, demographic, and health outcomes. Behavioral genetic analyses have mostly been concerned with decomposing the variation in the outcomes of interest into genetic, shared environmental, and non-shared environmental components, with recent multivariate analyses investigating the contributions of genes and the environment to the correlation and causation between variables. Despite the fact that twins studies and the recognition of the role of endowments are central to both of these literatures, they have mostly evolved independently. In this paper we develop formally the relationship between the economic and behavioral genetic approaches to the analyses of twins, and we develop an integrative approach that combines the identification of causal effects, which dominates the economic literature, with the decomposition of variances and covariances into genetic and environmental factors that are the primary goal of behavioral genetic approaches. We apply this integrative ACE-beta approach to an illustrative investigation of the impact of schooling on several demographic outcomes such as fertility and nuptiality and health.

摘要

双胞胎在经济学、社会学和行为遗传学中被广泛用于研究遗传禀赋在广泛的社会、人口和经济结果中所起的作用。然而,这些文献中的重点各不相同:经济文献主要关注在试图确定一个变量(通常是教育)对各种经济、人口和健康结果的影响的分析中,对未观察到的禀赋(包括作为一个重要子集的遗传禀赋)进行控制的必要性。行为遗传学分析主要关注将感兴趣的结果中的变异分解为遗传、共享环境和非共享环境成分,最近的多变量分析则研究基因和环境对变量之间的相关性和因果关系的贡献。尽管双胞胎研究以及对禀赋作用的认识在这两类文献中都很核心,但它们大多是独立发展的。在本文中,我们正式阐述了经济和行为遗传学方法在双胞胎分析中的关系,并开发了一种综合方法,该方法将主导经济文献的因果效应识别与将方差和协方差分解为遗传和环境因素(这是行为遗传学方法的主要目标)相结合。我们将这种综合的ACE-β方法应用于一个说明性研究,以考察教育对生育、婚姻状况和健康等几个人口学结果的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4ce/3158495/df0dfa423618/nihms297448f1.jpg

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