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来自长序榆根的抗炎内脂酸类似物。

Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii.

机构信息

Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.

出版信息

J Nat Prod. 2011 Sep 23;74(9):1875-80. doi: 10.1021/np200279r. Epub 2011 Aug 16.

DOI:10.1021/np200279r
PMID:21846089
Abstract

Bioassay-guided fractionation of roots of Beilschmiedia tsangii led to the isolation of six new endiandric acid analogues: tsangibeilin A (1), tsangibeilin B (2), endiandramide A (3), endiandric acid K (4), endiandric acid L (5), and endiandramide B (6). Also isolated were two new lignans, beilschminol A (7) and tsangin C (8), and six known compounds. The structures of 1-8 were determined by spectroscopic techniques. Compounds 3 and 6 exhibited potent iNOS inhibitory activity, with IC(50) values of 9.59 and 16.40 μM, respectively.

摘要

植物内生真菌次级代谢产物研究

穗花杉内生真菌的分离鉴定及其代谢产物研究

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