Chen Jih-Jung, Chou En-Tzu, Duh Chang-Yih, Yang Sheng-Zehn, Chen Ih-Sheng
Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, Taiwan, Republic of China.
Planta Med. 2006 Mar;72(4):351-7. doi: 10.1055/s-2005-916220.
Five new compounds including two tetrahydrofuran-type lignans, beilschmin A and beilschmin B, a dihydrofuran-type lignan, beilschmin C, and two 1-phenylbutyl benzoates, tsangin A and tsangin B, together with thirteen known compounds have been isolated from the stem of Beilschmiedia tsangii. The structures of these new compounds were determined through spectral analyses. Among the isolates, beilschmin A (1), beilschmin B (2), beilschmin C (3), tsangin A (4), tsangin B (5), 2,6,11-trimethyldodeca-2,6,10-triene (14), alpha-tocopherylquinone (17), and alpha-tocospiro B (18) were cytotoxic (IC (50) values < 4 microg/mL) in P-388 and/or HT-29 cell lines in vitro.
从樟叶琼楠茎中分离得到了5个新化合物，包括2个四氢呋喃型木脂素——琼楠素A和琼楠素B，1个二氢呋喃型木脂素——琼楠素C，以及2个1-苯基丁基苯甲酸酯类化合物——新琼楠素A和新琼楠素B，同时还分离得到了13个已知化合物。通过光谱分析确定了这些新化合物的结构。在分离得到的化合物中，琼楠素A（1）、琼楠素B（2）、琼楠素C（3）、新琼楠素A（4）、新琼楠素B（5）、2,6,11-三甲基十二碳-2,6,10-三烯（14）、α-生育酚醌（17）和α-生育螺酚B（18）在体外P-388和/或HT-29细胞系中具有细胞毒性（IC50值<4μg/mL）。
