Moro F, Scapagnini U, Gorgone G, Reina R, Scaletta S, Drago F
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1979 Feb 8;209(4):225-30. doi: 10.1007/BF00419056.
Chemical sympathectomy of the anterior segment of the eye was performed in rabbits with 6-hydroxydopamine (6-OHDA) intravitreously injected. The response of the pupillary diameter (PD) and intraocular pressure (IOP) to NE, E and Isoproterenol was determined through instillation of the drugs in the pretreated and control eyes. The results were as follows: 1) Both PD and IOP at different intervals of time from the injection show a sharp decrease in the treated eye. 2) About four weeks after the injection, the instillation of NE and E increases the PD only in the 6-OHDA pretreated eyes, while IP administration is not effective on both control and pretreated eyes. 3) The instillation of the three drugs, while decreasing IOP in the control eyes, does not modify the already low IOP in the pretreated eyes. The authors suggest the presence of a postdenervation supersensitivity affecting only the alpha receptors, since the beta stimulant IP is inactive in both treated and untreated eyes.
通过向兔眼玻璃体内注射6-羟基多巴胺（6-OHDA）进行眼前节化学性交感神经切除术。通过向预处理眼和对照眼中滴注药物来测定瞳孔直径（PD）和眼压（IOP）对去甲肾上腺素（NE）、肾上腺素（E）和异丙肾上腺素的反应。结果如下：1）注射后不同时间间隔的PD和IOP在治疗眼中均急剧下降。2）注射后约四周，滴注NE和E仅在6-OHDA预处理眼中使PD增加，而异丙肾上腺素（IP）给药对对照眼和预处理眼均无效。3）三种药物滴注时，虽使对照眼的IOP降低，但对预处理眼中已降低的IOP无影响。作者认为存在仅影响α受体的去神经后超敏反应，因为β激动剂IP在治疗眼和未治疗眼中均无活性。
