Colasanti B K, Trotter R R
Ann Ophthalmol. 1978 Sep;10(9):1209-14.
The influence of adrenergic and cholinergic drugs on intraocular pressure after chemical sympathectomy produced by 6-hydroxydopamine has been examined in rabbits. For comparison, ocular tension in response to these same drugs has been measured after chronic treatment of rabbits with the norepinephrine synthesis inhibitor alpha-methyl-para-tyrosine. The results indicated that the effects of these 2 treatments were both qualitatively and quantitatively similar. In both cases, supersensitivity to the pressure-lowering effects of alpha and beta adrenergic amines developed. After administration of cholinergic drugs, however, ocular tension became elevated to values ranging from 3 to 7 mm Hg above the baseline levels.
已经在兔子身上研究了肾上腺素能和胆碱能药物对6-羟基多巴胺所致化学性交感神经切除术后眼压的影响。为作比较，在用去甲肾上腺素合成抑制剂α-甲基-对-酪氨酸长期治疗兔子后，测量了其对这些相同药物的眼压反应。结果表明，这两种治疗的效果在定性和定量方面均相似。在这两种情况下，对α和β肾上腺素能胺的降压作用均出现超敏反应。然而，在给予胆碱能药物后，眼压升高至比基线水平高3至7毫米汞柱的值。
