锂的副作用研究。
A study of side effects of lithium.
机构信息
Professor & Head, Institute of Psychiatry, Govt. Rajaji Hospital and Madurai Medical College, Madurai.
出版信息
Indian J Psychiatry. 1983 Apr;25(2):87-93.
The present report is a study on the side effects experienced by the patients attending the Lithium Clinic of the Institute of Psychiatry, Government Rajaji Hospital, Madurai. Out of the 120 (M 78, F42) patients studied, 97 had side effects. The effects were examined in respect of their frequency, time of onset and course, their relation to one dose and serum levels of lithium and to the clinical response. The duration of therapy ranged from 3 months to 6 years.The most frequent side effects were tremors (26.6%) and polyuria (20.8%). The side effects occurred at varying periods from the onset of therapy. During the first 3 months, tremors, excess salivation, nausea and abdominal discomfort; weight gain, memory defects and polyuria, between 3 months and 1 year; and hypothyroidism, tardive dyskinesia, acne and hair fall beyond one year.
本报告是对在马德拉斯政府拉贾吉医院精神病学研究所锂诊所就诊的患者所经历的副作用进行的研究。在研究的 120 名患者（男性 78 名，女性 42 名）中，有 97 名出现了副作用。研究考察了副作用的频率、发病时间和病程、与单剂量和血清锂水平的关系以及与临床反应的关系。治疗时间从 3 个月到 6 年不等。最常见的副作用是震颤（26.6%）和多尿（20.8%）。副作用在治疗开始后的不同时间出现。在前 3 个月，出现震颤、唾液过多、恶心和腹部不适；体重增加、记忆缺陷和多尿在 3 个月至 1 年内；甲状腺功能减退、迟发性运动障碍、痤疮和脱发则在 1 年以上。
Zotero 插件