精神病学药物监测计划-药物不良反应。
Drug surveillance programme in psychiatry - adverse durg reactions.
机构信息
Prof. of Psychiatry, Department of Psychiatry & Department of Pharmacology & Clinical Pharmacology Unit, Seth G. S. Medical College & K.E.M. Hospital, Parel, Bombay 400 012.
出版信息
Indian J Psychiatry. 1983 Jul;25(3):229-34.
In a clinically monitored surveillance of adverse drug reactions in a sample of 186 indoor patients in a general hospital over an average hospital stay of about two weeks, the following points were noteworthy. 32.8% of the patients reported side-effects and of these 79.3% were of mild to moderate intensity.Side-effects could be easily managed by specific antidotes and reassurance and permitted continuation of the same medication.There was no association between side-effects and socio-demography or clinical characteristics of the patient. Side-effects fitted in with the pharmacological profiles of the drugs used. In only 7.3% of cases was major treatment change made after the occurrence of the side effect. Improvement was independent of side-effects and no unusual or toxic reactions were seen.
在一项对一家综合医院 186 名住院患者进行的药物不良反应临床监测研究中，平均住院时间约为两周。以下几点值得注意。报告有副作用的患者占 32.8%，其中 79.3%为轻度至中度强度。通过特定的解毒剂和安慰可以轻松管理副作用，并允许继续使用相同的药物。副作用与患者的社会人口统计学或临床特征之间没有关联。副作用与所用药物的药理学特征相符。仅在 7.3%的情况下，在发生副作用后才对治疗方案进行重大更改。改善与副作用无关，也未观察到异常或有毒反应。
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