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高血压患者的抑郁情况。

Depression in hypertensive subjects.

机构信息

Addl. Professor of Psychiatry, Madras Medical College & Neuropsychiatrist, Institute of Mental Health, Madrus-600 010.

出版信息

Indian J Psychiatry. 1983 Oct;25(4):260-3.

PMID:21847301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3012297/
Abstract

168 patients attending hypertension clinic were randomly selected for the study. They were thoroughly investigated using E.C.G., X-ray chest, Urine analysis, Blood sugar, Blood urea, Serum cholesterol, Serum K, Serum Na, Scrum creatinine and Uric acid level. Detailed psychiatric case history and mental examination was carried out. Beck Rating Scale was used to measure the depression. 25% of hypertensive subjects exhibited depressive features and their mean score in Beck Rating scale is 21.76. The mean score of non-depressives is 4.46. All patients were receiving methyl dopa.25 mg. twice or thrice daily with thiazide diuretic. No significant difference in the incidence of depression with the duration of medication was observed.The hypertension was classified into mild, moderate and severe depending on the diastolic pressure. Depression was more frequent in severe hypertensives but not to the statistically significant level.Further hypertensives were classified into:1. Hypertension without organ involvement2. Hypertension with LVH only3. Hypertension with additional organ involvement4. Malignant hypertensionDepression was significantly more frequent in hypertensives with complications and also hypertensives in whom the B.P. remained uncontrolled. As all the patients were on the same drug, the drug effect is common to all; hence, the higher incidence of depression in hypertensives with complications is due to the limitation and distress caused by the illness.

摘要

随机选择了 168 名高血压门诊患者进行研究。他们接受了详细的心电图、胸部 X 光、尿液分析、血糖、血尿素、血清胆固醇、血清钾、血清钠、血清肌酐和尿酸水平检查。进行了详细的精神病学病史和精神检查。使用贝克抑郁量表评估抑郁。25%的高血压患者表现出抑郁特征,他们在贝克抑郁量表中的平均得分为 21.76。非抑郁患者的平均得分是 4.46。所有患者均接受甲基多巴治疗,每天两次或三次,联合噻嗪类利尿剂。未观察到药物治疗时间长短与抑郁发生率之间存在显著差异。根据舒张压将高血压分为轻度、中度和重度。严重高血压患者的抑郁更为常见,但未达到统计学显著水平。进一步将高血压患者分为:1. 无器官受累的高血压;2. 仅左心室肥厚的高血压;3. 伴有其他器官受累的高血压;4. 恶性高血压。有并发症的高血压患者和血压控制不佳的高血压患者抑郁更为常见。由于所有患者都使用相同的药物,因此药物效应对所有人都是相同的;因此,并发症高血压患者中抑郁发生率较高是由于疾病带来的限制和痛苦。

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本文引用的文献

1
NEUROTICISM AND HYPERTENSION IN AN OUT-PATIENT POPULATION.门诊人群中的神经质与高血压
J Psychosom Res. 1964 Dec;8:235-8. doi: 10.1016/0022-3999(64)90049-2.
2
Personality and hypertension.个性与高血压。
J Psychosom Res. 1973 Jan;17(1):35-41. doi: 10.1016/0022-3999(73)90085-8.
3
Side effects of hypotensive agents evaluated by a self-administered questionnaire.通过自行填写问卷评估降压药的副作用。
Br Med J. 1973 Sep 1;3(5878):485-90. doi: 10.1136/bmj.3.5878.485.
4
Do antihypertensive drugs really cause depression?降压药真的会导致抑郁症吗?
Proc R Soc Med. 1974 Sep;67(9):919-21. doi: 10.1177/003591577406700937.