Bulpitt C J, Dollery C T
Br Med J. 1973 Sep 1;3(5878):485-90. doi: 10.1136/bmj.3.5878.485.
A self-administered symptom questionnaire was completed by 477 patients in a hypertension clinic. The complaints of the patients were analysed according to the type of therapy being given and the dose of drug taken. Methyldopa therapy was associated with sleepiness, weakness of the limbs, sleeping longer at night, and rising more frequently at night to pass urine. Diarrhoea, impotence, failure of ejaculation, blurred vision, depression, and the symptoms of postural hypotension were not related to methyldopa therapy. Bethanidine administration was related to postural hypotension, impotence, and failure of ejaculation but not to weakness of the limbs, blurred vision, depression, or diarrhoea. Patients receiving guanethidine complained of postural hypotension, failure of ejaculation, and had their bowels open more frequently. Similarly, patients receiving propranolol had an increased frequency of defaecation but also tended to complain of weakness of the limbs.Considering each drug individually, 5% of patients failed to take the prescribed dose of diuretic whereas
一家高血压诊所的477名患者完成了一份自我管理的症状调查问卷。根据所接受的治疗类型和所服用药物的剂量对患者的主诉进行了分析。甲基多巴治疗与嗜睡、四肢无力、夜间睡眠时间延长以及夜间更频繁起床排尿有关。腹泻、阳痿、射精障碍、视力模糊、抑郁以及体位性低血压症状与甲基多巴治疗无关。服用苄胍与体位性低血压、阳痿和射精障碍有关，但与四肢无力、视力模糊、抑郁或腹泻无关。接受胍乙啶治疗的患者主诉有体位性低血压、射精障碍，且排便更频繁。同样，接受普萘洛尔治疗的患者排便频率增加，但也往往主诉四肢无力。单独考虑每种药物时，5%的患者未按规定剂量服用利尿剂，而……
