Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Nuffield Orthopaedic Centre, Oxford, UK.
Skeletal Radiol. 2011 Sep;40(9):1137-40. doi: 10.1007/s00256-011-1180-9. Epub 2011 Aug 17.
Bone resorption is required for skeletal modelling during bone growth and for mineral homeostasis and bone remodelling throughout life. Osteoclasts are multinucleated cells that are uniquely specialised to carry out this physiological bone resorption. As osteolysis is a feature of most diseases of bone and joint, osteoclasts also play a role in pathological bone resorption, the extent of which is a function of the cellular and molecular mechanisms that govern their formation and function.
骨吸收对于骨骼生长期间的骨骼重塑以及整个生命周期中的矿物质稳态和骨重塑是必需的。破骨细胞是具有多核的细胞，专门用于进行这种生理骨吸收。由于溶骨性是大多数骨骼和关节疾病的特征，破骨细胞在病理性骨吸收中也发挥作用，其程度是控制其形成和功能的细胞和分子机制的功能。
