Moolten M, Kornetsky C
Boston University School of Medicine, MA 02118.
Alcohol. 1990 May-Jun;7(3):221-5. doi: 10.1016/0741-8329(90)90008-z.
The effects of ethanol on brain-stimulation reward (BSR) were investigated in rats orally self-administering ethanol. Electrodes were stereotaxically implanted in the medial forebrain bundle (MFB) of male F-344 rats. A rate free threshold procedure was used. Animals demonstrated significant threshold-lowering effects after considerable ethanol self-administration experience. To elucidate the significance of the contingent nature of the route of administration in the threshold-lowering effects of ethanol on BSR, a comparison of animals self-administering ethanol to yoked animals receiving it passively through a gastric cannula was made. Significant threshold-lowering effects were only found in the animals self-administering ethanol and not those receiving it noncontingently. Thus, to the extent that brain-stimulation reward is a model of drug-induced euphoria, these results suggest that the reinforcing effects of ethanol are dependent to a greater degree on an interaction between experimental, environmental and pharmacological factors, than other abused drugs.
在经口自行摄入乙醇的大鼠中研究了乙醇对脑刺激奖赏（BSR）的影响。将电极立体定位植入雄性F-344大鼠的内侧前脑束（MFB）。采用无速率阈值程序。在有大量乙醇自行摄入经历后，动物表现出显著的阈值降低效应。为了阐明给药途径的偶然性在乙醇对BSR阈值降低效应中的重要性，对自行摄入乙醇的动物与通过胃插管被动接受乙醇的配对动物进行了比较。仅在自行摄入乙醇的动物中发现了显著的阈值降低效应，而在非偶然性接受乙醇的动物中未发现。因此，就脑刺激奖赏是药物诱发欣快感的模型而言，这些结果表明，与其他滥用药物相比，乙醇的强化作用在更大程度上依赖于实验、环境和药理学因素之间的相互作用。
