Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, CF14 4XN, United Kingdom.
J Immunol. 2011 Sep 15;187(6):2944-52. doi: 10.4049/jimmunol.1101021. Epub 2011 Aug 17.
IL-10 is an immunomodulatory cytokine that acts to antagonize T cell responses elicited during acute and chronic infections. Thus, the IL-10R signaling pathway provides a potential therapeutic target in strategies aimed at combating infectious diseases. In this study, we set out to investigate whether IL-10 expression had an effect on NK cells. Murine CMV infection provides the best characterized in vivo system to evaluate the NK cell response, with NK cells being critical in the early control of acute infection. Blockade of IL-10R during acute murine CMV infection markedly reduced the accumulation of cytotoxic NK cells in the spleen and lung, a phenotype associated with a transient elevation of virus DNA load. Impaired NK cell responsiveness after IL-10R blockade was attributed to elevated levels of apoptosis observed in NK cells exhibiting an activated phenotype. Therefore, we conclude that IL-10 contributes to antiviral innate immunity during acute infection by restricting activation-induced death in NK cells.
白细胞介素-10（IL-10）是一种免疫调节细胞因子，可拮抗急性和慢性感染期间 T 细胞应答。因此，IL-10R 信号通路为旨在对抗传染病的策略提供了一个潜在的治疗靶点。在这项研究中，我们着手研究白细胞介素-10 的表达是否对自然杀伤（NK）细胞有影响。小鼠巨细胞病毒（CMV）感染提供了评估 NK 细胞反应的最佳体内系统，NK 细胞在急性感染的早期控制中至关重要。在急性小鼠 CMV 感染期间阻断 IL-10R 可显著减少脾脏和肺部细胞毒性 NK 细胞的积累，这种表型与病毒 DNA 载量的短暂升高有关。阻断 IL-10R 后 NK 细胞反应受损归因于观察到的激活表型 NK 细胞中凋亡水平升高。因此，我们得出结论，IL-10 通过限制 NK 细胞中激活诱导的死亡，在急性感染期间有助于抗病毒固有免疫。
