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多形性胶质母细胞瘤采用调强放射治疗的患者规范质量保证。

Patient specification quality assurance for glioblastoma multiforme brain tumors treated with intensity modulated radiation therapy.

机构信息

King Faisal Specialist Hospital & Research Centre, Dept. of Biomedical Physics, Riyadh 11211, Saudi Arabia.

出版信息

Int J Med Sci. 2011;8(6):461-6. doi: 10.7150/ijms.8.461. Epub 2011 Aug 2.

DOI:10.7150/ijms.8.461
PMID:21850196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3156993/
Abstract

The aim of this study was to evaluate the significance of performing patient specification quality assurance for patients diagnosed with glioblastoma multiforme treated with intensity modulated radiation therapy. The study evaluated ten intensity modulated radiation therapy treatment plans using 10 MV beams, a total dose of 60 Gy (2 Gy/fraction, five fractions a week for a total of six weeks treatment). For the quality assurance protocol we used a two-dimensional ionization-chamber array (2D-ARRAY). The results showed a very good agreement between the measured dose and the pretreatment planned dose. All the plans passed >95% gamma criterion with pixels within 5% dose difference and 3 mm distance to agreement. We concluded that using the 2D-ARRAY ion chamber for intensity modulated radiation therapy is an important step for intensity modulated radiation therapy treatment plans, and this study has shown that our treatment planning for intensity modulated radiation therapy is accurately done.

摘要

本研究旨在评估对接受调强放射治疗的多形性胶质母细胞瘤患者进行患者规范质量保证的意义。该研究使用 10MV 射线评估了 10 个调强放射治疗计划，总剂量为 60Gy（2Gy/分次，每周 5 次，共 6 周治疗）。对于质量保证方案，我们使用了二维电离室阵列（2D-ARRAY）。结果表明，测量剂量与预处理计划剂量之间具有非常好的一致性。所有计划均通过 >95%的伽马标准，像素之间的剂量差异小于 5%，距离一致小于 3mm。我们得出结论，使用 2D-ARRAY 离子室进行调强放射治疗是调强放射治疗计划的重要步骤，本研究表明我们的调强放射治疗计划是准确完成的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/3156993/a9f24bd14187/ijmsv08p0461g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/3156993/320fc04ba6a1/ijmsv08p0461g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/3156993/83754cd04210/ijmsv08p0461g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/3156993/c7ea0ab8efd9/ijmsv08p0461g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/3156993/a9f24bd14187/ijmsv08p0461g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/3156993/320fc04ba6a1/ijmsv08p0461g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/3156993/83754cd04210/ijmsv08p0461g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/3156993/c7ea0ab8efd9/ijmsv08p0461g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/3156993/a9f24bd14187/ijmsv08p0461g04.jpg

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本文引用的文献

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Necroptosis: a novel therapeutic target for glioblastoma.细胞程序性坏死：胶质母细胞瘤的一种新的治疗靶点。
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A clinicopathological and molecular analysis of glioblastoma multiforme with long-term survival.胶质母细胞瘤伴长期生存的临床病理和分子分析。
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The angular dependence of a 2-dimensional diode array and the feasibility of its application in verifying the composite dose distribution of intensity-modulated radiation therapy.二维二极管阵列的角度依赖性及其在验证调强放射治疗复合剂量分布中的应用可行性。
Chin J Cancer. 2010 Jun;29(6):617-20. doi: 10.5732/cjc.009.10592.
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Recent advances in radiotherapy.放射治疗的最新进展。
BMC Med. 2010 Apr 28;8:25. doi: 10.1186/1741-7015-8-25.
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Spinal metastasis of glioblastoma multiforme: an uncommon suspect?胶质母细胞瘤的脊柱转移：一个不常见的嫌疑犯？
Spine (Phila Pa 1976). 2010 Apr 1;35(7):E264-9. doi: 10.1097/BRS.0b013e3181c11748.
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Intensity modulated radiotherapy (IMRT) in benign giant cell tumors--a single institution case series and a short review of the literature.调强放疗（IMRT）治疗良性骨巨细胞瘤的单中心病例系列研究及文献复习
Radiat Oncol. 2010 Feb 26;5:18. doi: 10.1186/1748-717X-5-18.
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