Department of Nutritional Sciences, The University of Texas at Austin, School of Human Ecology, Austin, TX 78712, USA.
Int J Oncol. 2011 Dec;39(6):1443-53. doi: 10.3892/ijo.2011.1162. Epub 2011 Aug 17.
The risk of developing breast cancer and fatty liver is increased by alcohol consumption. The objective of the present study was to determine if obesity and exogenous estrogen supplementation alter the effects of alcohol on mammary tumorigenesis and fatty liver. Ovariectomized female mice were (1) fed diets to induce overweight and obese phenotypes, (2) provided water or 20% alcohol, (3) implanted with placebo, low- or high-dose estrogen pellets and (4) injected with Met-1 mouse mammary cancer cells. Alcohol-consuming mice were more insulin sensitive and developed larger tumors than water consuming mice. Obese mice developed slightly larger tumors than control mice. Alcohol consumption and obesity increased growth factors, hepatic steatosis, activation of Akt, and inhibited the caspase-3 cascade. Estrogen treatment triggered the loss of body fat, induced insulin sensitivity, suppressed tumor growth, reduced growth factors and improved hepatic steatosis. Results show that the effects of alcohol on mammary tumor and fatty liver are modified by obesity and estrogen supplementation.
饮酒会增加罹患乳腺癌和脂肪肝的风险。本研究的目的是确定肥胖和外源性雌激素补充是否会改变酒精对乳腺肿瘤发生和脂肪肝的影响。去卵巢雌性小鼠（1）喂食诱导超重和肥胖表型的饮食，（2）提供水或 20%酒精，（3）植入安慰剂、低剂量或高剂量雌激素丸，（4）注射 Met-1 小鼠乳腺癌细胞。饮酒小鼠比饮水小鼠更敏感胰岛素，肿瘤更大。肥胖小鼠的肿瘤比对照小鼠稍大。饮酒和肥胖增加了生长因子、肝脂肪变性、Akt 的激活，并抑制了 caspase-3 级联反应。雌激素治疗可导致体脂丢失、诱导胰岛素敏感性、抑制肿瘤生长、减少生长因子并改善肝脂肪变性。结果表明，肥胖和雌激素补充改变了酒精对乳腺肿瘤和脂肪肝的影响。
