外源性雌激素可保护小鼠免受肥胖和酒精的影响。
Exogenous estrogen protects mice from the consequences of obesity and alcohol.
机构信息
Department of Nutritional Sciences, School of Human Ecology, College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA.
出版信息
Menopause. 2012 Jun;19(6):680-90. doi: 10.1097/gme.0b013e31823cf6ee.
OBJECTIVE
Breast cancer is the second leading cause of cancer death among American women. Risk factors for breast cancer include obesity, alcohol consumption, and estrogen therapy. In the present studies, we determine the simultaneous effects of these three risk factors on wingless int (Wnt)-1 mammary tumor growth.
METHODS
Ovariectomized female mice were fed diets to induce different body weights (calorie restricted, low fat, high fat), provided water or 20% alcohol, implanted with placebo or estrogen pellets and injected with Wnt-1 mouse mammary cancer cells.
RESULTS
Our results show that obesity promoted the growth of Wnt-1 tumors and induced fatty liver. Tumors tended to be larger in alcohol-consuming mice and alcohol exacerbated fatty liver in obese mice. Estrogen treatment promoted weight loss in obese mice, which was associated with the suppression of tumor growth and fatty liver.
CONCLUSIONS
In summary, we show that estrogen protects against obesity, which is associated with the inhibition of fatty liver and tumor growth.
目的
乳腺癌是美国女性癌症死亡的第二大主要原因。乳腺癌的风险因素包括肥胖、饮酒和雌激素治疗。在本研究中，我们确定了这三个风险因素对无翅型 int（Wnt）-1 乳腺肿瘤生长的同时影响。
方法
去卵巢雌性小鼠喂食不同热量的饮食（限制热量、低脂、高脂），给予水或 20%酒精，植入安慰剂或雌激素丸，并注射 Wnt-1 小鼠乳腺癌细胞。
结果
我们的结果表明，肥胖促进了 Wnt-1 肿瘤的生长并导致脂肪肝。饮酒的小鼠肿瘤往往更大，而肥胖小鼠的酒精会加剧脂肪肝。雌激素治疗促进了肥胖小鼠的体重减轻，这与肿瘤生长和脂肪肝的抑制有关。
结论
总之，我们表明雌激素可预防肥胖，这与抑制脂肪肝和肿瘤生长有关。
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