Abadie E, Marre M, Race J M, Luis N, Passa P
Service de Diabétologie, Hôpital Saint-Louis, Paris.
Diabete Metab. 1990 Jan-Feb;16(1):7-10.
To explore simultaneously the effects on insulin secretion and on vascular tone of YC 170, a new dihydropyridine derivative calcium agonist, isolated perfused rat pancreases were studied for insulin output and for duodenopancreatic resistances before, during and after exposure to YC 170 10(-4) M (n = 15) or its solvent (n = 10). Although insulin was stimulated transiently during the five first minutes following addition of YC 170 (p less than 0.01) the integrated insulin output measured during the whole experiments was not different with YC 170 from that observed with solvent. Conversely, the initial duodenopancreatic resistances (22 +/- 4 mmHg.ml-1.min-1) rose progressively with YC 170 up to maximal values at the end of experiments (104 +/- 28 mmHg.ml-1.min-1; p less than 0.01); no significant variation occurred with solvent. Vascular and insulinotropic effects of YC 170 can be dissociated, suggesting variable abilities to promote calcium transport across membranes of smooth muscle cells and of pancreatic B-cells.
为了同时探究新型二氢吡啶衍生物钙激动剂YC 170对胰岛素分泌和血管张力的影响，我们对分离灌注的大鼠胰腺进行了研究，以检测在暴露于10(-4)M YC 170（n = 15）或其溶剂（n = 10）之前、期间和之后的胰岛素分泌量以及十二指肠胰腺阻力。尽管在添加YC 170后的最初五分钟内胰岛素分泌出现短暂增加（p < 0.01），但在整个实验过程中测得的胰岛素分泌总量在使用YC 170时与使用溶剂时并无差异。相反，初始十二指肠胰腺阻力（22 +/- 4 mmHg.ml-1.min-1）在使用YC 170时逐渐升高，在实验结束时达到最大值（104 +/- 28 mmHg.ml-1.min-1；p < 0.01）；而使用溶剂时未出现显著变化。YC 170的血管作用和促胰岛素作用可以分离，这表明其促进钙跨平滑肌细胞和胰腺B细胞膜转运的能力存在差异。
