Department of Pharmaceutical Chemistry, College of Pharmacy, AlKharj University, Saudi Arabia.
J Enzyme Inhib Med Chem. 2012 Aug;27(4):541-5. doi: 10.3109/14756366.2011.601302. Epub 2011 Aug 18.
Twenty-two quinazoline derivatives have been synthesised and examined for their anti-tumour activity against three tumour cell lines, namely human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa) and human hepatoma cell line (HepG2). Twelve of the tested compounds have shown promising anti-tumour activity with an IC(50) range of 5.0-9.7 µg/mL. Regarding the spectrum of activity, five compounds exhibited interesting anti-proliferative properties against the three tested cell lines comparable to the reference drug (dasatinib).
已经合成了 22 种喹唑啉衍生物，并对它们的抗肿瘤活性进行了测试，针对三种肿瘤细胞系，即人乳腺癌细胞系（MCF-7）、人宫颈癌细胞系（HeLa）和人肝癌细胞系（HepG2）。在测试的 12 种化合物中，有 12 种表现出了有希望的抗肿瘤活性，IC（50）范围在 5.0-9.7μg/ml 之间。关于活性谱，有 5 种化合物对三种测试的细胞系表现出了有趣的抗增殖特性，与参考药物（达沙替尼）相当。
