Department of Pharmaceutical Chemistry, College of Pharmacy, Salman Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
J Enzyme Inhib Med Chem. 2013 Apr;28(2):375-83. doi: 10.3109/14756366.2012.668541. Epub 2012 Apr 2.
New series of quinazoline containing sulfonamide derivatives were prepared and screened for their antitumor activity. Four human cancer cell lines, namely, hepatoma cancer cell line (HepG2), breast cancer cell line (MCF-7), cervix cancer cell line (HeLa) and colon cancer cell line (HCT-8), were used to measure the cytotoxic activity. Compounds 8 and 21 exhibited remarkable antitumor activity almost similar to that of the standard drug (doxorubicin). Six compounds 16, 22, 23, 29, 30 and 33, showed considerable activity and few compounds were totally inactive.
新系列含喹唑啉的磺酰胺衍生物被制备并筛选其抗肿瘤活性。四种人癌细胞系，即肝癌细胞系（HepG2）、乳腺癌细胞系（MCF-7）、宫颈癌细胞系（HeLa）和结肠癌细胞系（HCT-8），用于测量细胞毒性活性。化合物 8 和 21 表现出显著的抗肿瘤活性，几乎与标准药物（阿霉素）相当。六种化合物 16、22、23、29、30 和 33 表现出相当的活性，而少数化合物则完全没有活性。
