Murai T, Ogawa Y, Kawasaki H
National Institute of Hygienic Sciences, Osaka Branch, Japan.
FEMS Microbiol Lett. 1990 Mar 1;56(1-2):61-4. doi: 10.1111/j.1574-6968.1990.tb04122.x.
Pretreatment of rabbits with streptococcal pyrogenic exotoxin (SPE) resulted in an enhancement of their febrile response to subsequent endotoxin challenge. This suggested that SPE may enhance the macrophage capacity to respond to endotoxin in vivo to produce an endogenous pyrogen. It was also demonstrated that peritoneal macrophages derived from SPE-treated rabbits exhibited hyperreactivity to endotoxin in vitro as assessed by endotoxin-induced increase in glucose consumption. These data indicate that SPE has the ability to enhance macrophage reactivity to endotoxin.
用链球菌致热外毒素（SPE）对兔子进行预处理，会增强它们对随后内毒素攻击的发热反应。这表明SPE可能增强巨噬细胞在体内对内毒素作出反应以产生内源性致热原的能力。研究还表明，从经SPE处理的兔子获得的腹腔巨噬细胞，在体外对内毒素表现出高反应性，这是通过内毒素诱导的葡萄糖消耗增加来评估的。这些数据表明，SPE有能力增强巨噬细胞对内毒素的反应性。
