Murai T, Ogawa Y, Kawasaki H
National Institute of Hygienic Sciences, Osaka Branch, Japan.
FEMS Microbiol Lett. 1990 Jun 1;57(3):201-4. doi: 10.1016/0378-1097(90)90065-x.
Streptococcal pyrogenic exotoxin (SPE) showed no direct effect on rabbit macrophage functions in vitro. However, when splenic lymphocytes were added to macrophage cultures, SPE caused marked augmentation of glucose consumption and superoxide anion production, and concomitant inhibition of phagocytosis without loss of cell viability. The SPE effects were demonstrated to be mediated by a soluble factor(s) released from the splenic lymphocytes in response to SPE stimulus.
链球菌致热外毒素（SPE）在体外对兔巨噬细胞功能无直接影响。然而，当将脾淋巴细胞加入巨噬细胞培养物中时，SPE会导致葡萄糖消耗和超氧阴离子产生显著增加，同时抑制吞噬作用，且细胞活力无损失。已证明SPE的作用是由脾淋巴细胞在SPE刺激下释放的一种或多种可溶性因子介导的。
