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神经外科术后细菌性脑膜炎患者脑脊液和血清中利奈唑胺的药代动力学及蛋白结合情况

Pharmacokinetics and protein binding of linezolid in cerebrospinal fluid and serum in a case of post-neurosurgical bacterial meningitis.

作者信息

Tsuji Yasuhiro, Hiraki Yoichi, Matsumoto Kana, Mizoguchi Akiko, Sadoh Shinichi, Kobayashi Tsutomu, Takemura Yusuke, Sakamoto Seisaburo, Morita Kunihiko, Kamimura Hidetoshi, Karube Yoshiharu

机构信息

Department of Pharmacy, Sasebo Chuo Hospital, Sasebo, Nagasaki, Japan.

出版信息

Scand J Infect Dis. 2011 Dec;43(11-12):982-5. doi: 10.3109/00365548.2011.600327. Epub 2011 Aug 19.

DOI:10.3109/00365548.2011.600327
PMID:21851332
Abstract

We describe a case of bacterial meningitis in a patient administered linezolid (LZD). The ratio of free to total LZD concentrations in cerebrospinal fluid (CSF) was 1 for all measurements, and the LZD concentration in CSF measured at the trough level was almost the same as the free serum concentration.

摘要

我们描述了一例接受利奈唑胺（LZD）治疗的患者发生细菌性脑膜炎的病例。脑脊液（CSF）中游离利奈唑胺与总利奈唑胺浓度的比值在所有测量中均为1，且谷浓度时测得的脑脊液中利奈唑胺浓度与游离血清浓度几乎相同。

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