Servicio Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS Dr Carlos G. Malbrán, Ciudad Autónoma de Buenos Aires, Argentina.
Clin Microbiol Infect. 2011 Oct;17(10):1520-4. doi: 10.1111/j.1469-0691.2011.03600.x. Epub 2011 Aug 18.
The present work describes the abrupt emergence of Klebsiella pneumoniae carbapenemase (KPC) and characterizes the first 79 KPC-producing enterobacteria from Argentina (isolated from 2006 to 2010). The emergence of bla(KPC-2) was characterized by two patterns of dispersion: the first was the sporadic occurrence in diverse enterobacteria from distant geographical regions, harbouring plasmids of different incompatibility groups and bla(KPC-2) in an unusual genetic environment flanked by ISKpn8-Δbla(TEM-1) and ISKpn6-like. bla(KPC-2) was associated with IncL/M transferable plasmids; the second was the abrupt clonal spread of K. pneumoniae ST258 harbouring bla(KPC-2) in Tn4401a.
本研究描述了产碳青霉烯酶肺炎克雷伯菌（KPC）的突然出现，并对来自阿根廷的 79 株产 KPC 肠杆菌（2006 年至 2010 年分离）进行了特征描述。bla(KPC-2)的传播有两种模式：第一种是在来自不同地理区域的不同肠杆菌中零星出现，携带不同不相容群的质粒，bla(KPC-2)位于一个不寻常的遗传环境中，两侧为 ISKpn8-Δbla(TEM-1)和 ISKpn6 样元件。bla(KPC-2)与可转移的 IncL/M 质粒有关；第二种是携带 bla(KPC-2)的 Tn4401a 型 K. pneumoniae ST258 的突然克隆传播。
