Shichiri M, Hirata Y, Ando K, Emori T, Ohta K, Kimoto S, Ogura M, Inoue A, Marumo F
Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Hypertension. 1990 May;15(5):493-6. doi: 10.1161/01.hyp.15.5.493.
Endothelin-1 is a novel endothelium-derived vasoconstrictive peptide. Using a highly specific and sensitive radioimmunoassay for endothelin-1, plasma levels of immunoreactive endothelin-1 were measured in 32 research subjects with normal renal function (21 normal subjects and 11 patients with essential hypertension), 24 patients with nondialyzed chronic renal failure, and 51 patients undergoing maintenance hemodialysis. Although there was no significant difference in plasma immunoreactive endothelin-1 levels among the three groups, patients with essential hypertension had significantly higher plasma endothelin-1 levels than normal subjects (2.29 +/- 1.09 vs. 1.41 +/- 0.50 pg/ml, p less than 0.025). When nondialyzed and hemodialyzed patients were divided into hypertensive and normotensive groups, the nondialyzed hypertensive group (n = 17) had higher plasma endothelin-1 levels than the comparable normotensive group (n = 7) (3.08 +/- 3.43 vs. 0.73 +/- 0.34 pg/ml, p less than 0.05), and the hemodialyzed hypertensive group (n = 18) had higher plasma endothelin-1 levels than the comparable normotensive group (n = 33) (2.66 +/- 1.92 vs. 1.35 +/- 0.73 pg/ml, p less than 0.005). Plasma atrial natriuretic factor, arginine vasopressin, renin activity, and aldosterone concentration did not show significant differences between hypertensive and normotensive individuals or a correlation with plasma endothelin-1 levels. These data suggest that circulating endothelin-1 may be partly involved in the development or maintenance of hypertension in humans.
内皮素 -1是一种新发现的内皮源性血管收缩肽。采用高度特异且灵敏的内皮素 -1放射免疫分析法，对32例肾功能正常的研究对象（21例正常人和11例原发性高血压患者）、24例未透析的慢性肾衰竭患者以及51例接受维持性血液透析的患者测定了血浆中免疫反应性内皮素 -1的水平。虽然三组间血浆免疫反应性内皮素 -1水平无显著差异，但原发性高血压患者的血浆内皮素 -1水平显著高于正常受试者（2.29±1.09对1.41±0.50 pg/ml，p<0.025）。当将未透析和透析患者分为高血压组和血压正常组时，未透析高血压组（n = 17）的血浆内皮素 -1水平高于相应的血压正常组（n = 7）（3.08±3.43对0.73±0.34 pg/ml，p<0.05），透析高血压组（n = 18）的血浆内皮素 -1水平高于相应的血压正常组（n = 33）（2.66±1.92对1.35±0.73 pg/ml，p<0.005）。血浆心钠素、精氨酸加压素、肾素活性和醛固酮浓度在高血压和血压正常个体之间未显示出显著差异，也与血浆内皮素 -1水平无相关性。这些数据提示，循环中的内皮素 -1可能部分参与了人类高血压的发生或维持。
