Kohno M, Yasunari K, Murakawa K, Yokokawa K, Horio T, Fukui T, Takeda T
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Am J Med. 1990 Jun;88(6):614-8. doi: 10.1016/0002-9343(90)90527-k.
Endothelin plays a role in the regulation of vascular tonus. Therefore, it has been hypothesized that increased production or release of endothelin or both may contribute to the pathogenesis of hypertension. To assess any changes in the plasma endothelin concentration in essential hypertension, plasma immunoreactive endothelin concentrations were measured in patients with essential hypertension.
We measured plasma immunoreactive endothelin concentrations in 42 subjects with essential hypertension, 12 subjects with borderline hypertension, and 25 normotensive control subjects.
The concentrations were higher in hypertensive patients than in borderline hypertensive patients and normotensive subjects (both p less than 0.05), although values in normotensives and hypertensives overlapped. Reverse-phase high-performance liquid chromatography (HPLC) and radioimmuno-assay showed two components of plasma endothelin, one corresponding to synthetic endothelin-1 (1-21) and the other corresponding to synthetic big endothelin (human, 1-38). The HPLC profile of plasma endothelin of hypertensive patients was the same as that of normotensive subjects. Hypertensives with reduced glomerular filtration rates or increased serum creatinine levels had higher plasma endothelin concentrations than hypertensive patients as a whole (p less than 0.05). Mean blood pressure and serum creatinine levels were correlated to plasma endothelin in the hypertensives. Correlation was negative between glomerular filtration rate and the endothelin level in the hypertensives.
Plasma endothelin was elevated in many hypertensive patients with severe hypertension or renal involvement. Its major components were endothelin-1 and big endothelin.
内皮素在血管张力调节中发挥作用。因此，有人提出内皮素生成增加或释放增加或两者兼而有之可能促成高血压的发病机制。为评估原发性高血压患者血浆内皮素浓度的任何变化，对原发性高血压患者的血浆免疫反应性内皮素浓度进行了测定。
我们测定了42例原发性高血压患者、12例临界高血压患者和25例血压正常对照者的血浆免疫反应性内皮素浓度。
高血压患者的浓度高于临界高血压患者和血压正常者（均P<0.05），尽管血压正常者和高血压患者的值有重叠。反相高效液相色谱法（HPLC）和放射免疫分析显示血浆内皮素有两种成分，一种对应于合成内皮素-1（1-21），另一种对应于合成大内皮素（人，1-38）。高血压患者血浆内皮素的HPLC图谱与血压正常者相同。肾小球滤过率降低或血清肌酐水平升高的高血压患者的血浆内皮素浓度高于总体高血压患者（P<0.05）。高血压患者的平均血压和血清肌酐水平与血浆内皮素相关。高血压患者的肾小球滤过率与内皮素水平呈负相关。
许多重度高血压或有肾脏受累的高血压患者血浆内皮素升高。其主要成分是内皮素-1和大内皮素。
