Kostov Krasimir, Blazhev Alexander
Department of Pathophysiology, Medical University-Pleven, 1 Kliment Ohridski Str., 5800 Pleven, Bulgaria.
Department of Biology, Medical University-Pleven, 1 Kliment Ohridski Str., 5800 Pleven, Bulgaria.
Pathophysiology. 2021 Oct 25;28(4):489-495. doi: 10.3390/pathophysiology28040031.
The role of endothelin-1 (ET-1) in the pathogenesis of hypertension (HTN) is not clearly established. There is evidence that its circulating levels are elevated in some forms of experimental and human HTN, but this was not a consistent finding. Based on these controversial data, we tested serum levels of ET-1 and Big ET-1 (the precursor of ET-1) in patients with essential HTN, comparing the results with those of healthy normotensive controls. The levels of ET-1 and Big ET-1 were measured by ELISA. Our results in patients with essential HTN showed that the mean levels of ET-1 (5.01 ± 2.1 pg/mL) were significantly higher ( = 6.34, = 0.0144) than the mean levels in the control group (3.2 ± 1.0 pg/mL). The levels of Big ET-1 in patients with essential HTN (0.377 ± 0.1 pmol/L) were similar to those in the control group (0.378 ± 0.07 pmol/L) and did not differ significantly ( = 0.00, = 0.9531). These data suggest that ET-1, but not Big ET-1, may play an important role in the pathogenesis of primary HTN.
内皮素-1（ET-1）在高血压（HTN）发病机制中的作用尚未明确确立。有证据表明，在某些形式的实验性高血压和人类高血压中，其循环水平会升高，但这并非是一个一致的发现。基于这些有争议的数据，我们检测了原发性高血压患者血清中ET-1和大ET-1（ET-1的前体）的水平，并将结果与健康血压正常的对照组进行比较。ET-1和大ET-1的水平通过酶联免疫吸附测定法（ELISA）进行测量。我们对原发性高血压患者的研究结果显示，ET-1的平均水平（5.01±2.1皮克/毫升）显著高于对照组的平均水平（3.2±1.0皮克/毫升）（t = 6.34，P = 0.0144）。原发性高血压患者中大ET-1的水平（0.377±0.1皮摩尔/升）与对照组（0.378±0.07皮摩尔/升）相似，且无显著差异（t = 0.00，P = 0.9531）。这些数据表明，ET-1而非大ET-1可能在原发性高血压的发病机制中起重要作用。
