Department of Urology, Changi General Hospital, Singapore.
BJU Int. 2012 Feb;109(4):622-5. doi: 10.1111/j.1464-410X.2011.10329.x. Epub 2011 Aug 18.
• To evaluate the long-term outcomes of patients undergoing observation of asymptomatic renal calculi.
• This is a retrospective review of 50 patients with 85 stones undergoing observation with annual imaging from January 2005 to December 2009. • The incidences of spontaneous stone passage, stone progression and intervention were evaluated and assessed for statistical difference according to initial size and location of stone. • Percutaneous nephrolithotomy, shock wave lithotripsy and ureteroscopy were performed when patients developed complications from the stones.
• Patients were followed up for a mean of 46 months. Sixteen percent had bilateral stones and 38% had multiple stones. • The average stone size was 5.7 mm and 31%, 26% and 43% of the stones were located in the upper, middle and lower pole respectively. • Overall incidences of spontaneous passage, progression and intervention were 20%, 45.9% and 7.1% respectively. • Stones measuring 5 mm or less were significantly more likely to pass (P= 0.006). • There was no significant difference in the incidence of passage according to the initial location of the stone (P= 0.092). There was no significant difference in intervention or progression according to the initial size (P= 0.477 and 0.282 respectively) or location of stone (P= 0.068 and 0.787 respectively).
• Patients with asymptomatic renal stones may be managed conservatively in view of low risk of intervention (7.1%). • Annual imaging should be performed as half of these stones will progress in size.
评估接受无症状肾结石观察治疗患者的长期结局。
这是一项回顾性研究,纳入了 2005 年 1 月至 2009 年 12 月期间接受观察治疗的 50 例 85 颗结石患者。评估了结石自发排出、进展和干预的发生率,并根据结石的初始大小和位置评估了统计差异。当患者出现结石相关并发症时,进行经皮肾镜碎石术、体外冲击波碎石术和输尿管镜检查。
患者平均随访 46 个月。16%的患者有双侧结石,38%的患者有多发性结石。结石的平均大小为 5.7mm,31%、26%和 43%的结石分别位于上极、中极和下极。自发排出、进展和干预的总发生率分别为 20%、45.9%和 7.1%。结石大小为 5mm 或以下的患者更有可能自行排出(P=0.006)。结石的初始位置与排出率无显著差异(P=0.092)。结石的初始大小(P=0.477)或位置(P=0.068 和 0.787)与干预或进展率均无显著差异。
鉴于干预的风险较低(7.1%),无症状肾结石患者可以采用保守治疗方法。应每年进行影像学检查,因为这些结石中有一半会增大。