Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, Scotland G61 1BD, UK.
Exp Cell Res. 2011 Nov 15;317(19):2725-31. doi: 10.1016/j.yexcr.2011.08.001. Epub 2011 Aug 7.
Loss of the APC (adenomatous polyposis coli) gene in colorectal cancer leads to a rapid deregulation of TCF/LEF target genes. Of all these target genes, the transcription factor c-MYC appears the most critical. In this review we will discuss the interplay of Wnt and c-MYC signaling during intestinal homeostasis and transformation. Furthermore, we will discuss recent data showing that further deregulation of c-MYC levels during colorectal carcinogenesis may drive tumor progression. Moreover, understanding these additional control mechanisms may allow targeting of c-MYC during colorectal carcinogenesis.
结直肠癌中 APC（腺瘤性结肠息肉病）基因的丢失导致 TCF/LEF 靶基因的快速失调。在所有这些靶基因中，转录因子 c-MYC 似乎最为关键。在这篇综述中，我们将讨论 Wnt 和 c-MYC 信号在肠道稳态和转化过程中的相互作用。此外，我们还将讨论最近的数据，表明在结直肠癌发生过程中 c-MYC 水平的进一步失调可能驱动肿瘤的进展。此外，了解这些额外的控制机制可能允许在结直肠癌发生过程中靶向 c-MYC。
