Medical Faculty of the Masaryk University, Brno, Czech Republic.
J Neurol Sci. 2011 Nov 15;310(1-2):279-82. doi: 10.1016/j.jns.2011.07.048. Epub 2011 Aug 17.
Our objective was to assess which clinical factors contribute most to the impairment of instrumental activities of daily living (IADL) in patients with dementia in Parkinson's disease (PDD) as compared to age- and dementia duration-matched patients with Alzheimer's disease (AD).
Eighteen consecutive subjects (16 men, 2 women) with PDD and 30 age- and dementia duration-matched subjects with AD (13 men, 17 women) were recruited. The groups were not matched for their Mini-Mental Status Examination (MMSE) score. Neuropsychiatric, cognitive and motor data were collected in a routine clinical setting using the MMSE, four brief tests of the seven minute screen (i.e. the Benton Temporal Orientation, Grober and Buschke's enhanced cued recall, verbal fluency, and the clock drawing test), the Neuropsychiatric Inventory, a modified version of the Hoehn and Yahr scale and a Czech modified version of Lawton's IADL questionnaire. The IADL scores were correlated with clinical variables in each group.
There were no differences in IADL abilities between both groups. A significant association was found between IADL and cognitive impairment as measured by screening tests in the AD group. In the PDD group, IADL scores were particularly correlated with PD duration (r=-0.73, p<0.01) and the Hoehn and Yahr score (r=-0.59, p<0.01).
Our pilot study results show that motor deficits remain the major contributor to IADL impairment in PDD.
我们的目的是评估与年龄和痴呆持续时间匹配的阿尔茨海默病（AD）患者相比，哪些临床因素对帕金森病（PD）伴痴呆（PDD）患者工具性日常生活活动（IADL）的损害影响最大。
招募了 18 名连续的 PDD 患者（16 名男性，2 名女性）和 30 名年龄和痴呆持续时间匹配的 AD 患者（13 名男性，17 名女性）。两组的简易精神状态检查（MMSE）评分不匹配。在常规临床环境中使用 MMSE、七分钟筛查的四个简短测试（即本顿时间定向测试、Grober 和 Buschke 的增强线索回忆测试、语言流畅性测试和时钟绘图测试）、神经精神病学量表、改良 Hoehn 和 Yahr 量表和捷克语修改版的 Lawton 的 IADL 问卷收集神经心理学、认知和运动数据。在每组中，IADL 评分与临床变量相关。
两组的 IADL 能力没有差异。在 AD 组中，IADL 与筛查测试测量的认知障碍之间存在显著相关性。在 PDD 组中，IADL 评分与 PD 持续时间（r=-0.73，p<0.01）和 Hoehn 和 Yahr 评分（r=-0.59，p<0.01）特别相关。
我们的初步研究结果表明，运动缺陷仍然是 PDD 患者 IADL 损害的主要原因。
