Sabbagh M N, Lahti T, Connor D J, Caviness J N, Shill H, Vedders L, Mahant P, Samanta J, Burns R S, Evidente V G H, Driver-Dunckley E, Reisberg B, Bircea S, Adler C H
The Cleo Roberts Center for Clinical Research, Sun Health Research Institute, Sun City, AZ 85351, USA.
Dement Geriatr Cogn Disord. 2007;24(5):327-34. doi: 10.1159/000108340. Epub 2007 Sep 13.
BACKGROUND/AIMS: Previously we have shown that functional declines in Parkinson's disease (PD) and Alzheimer's disease (AD) correlate to global measures of cognitive decline. We now determine if the correlation between cognitive impairment and functional ability in PD is similar to that in AD using individual cognitive measures.
93 PD subjects and 124 AD/MCI subjects underwent the Functional Assessment Staging (FAST), the Global Deterioration Scale (GDS), and a neuropsychological battery.
In PD subjects, the FAST and GDS correlated significantly with Rey Auditory Verbal Learning Test (AVLT), Controlled Oral Word Association (COWA), Animal Fluency, and Stroop but not with Clock Draw or Judgment Line Orientation (JLO). In AD/MCI subjects, FAST and GDS correlated with all neuropsychological components except Stroop. In the AD/MCI group, the UPDRS significantly correlated with the FAST, GDS, MMSE, and all neuropsychological parameters except the Stroop. In the PD group, the motor UPDRS significantly correlated significantly with FAST, GDS, MMSE and all neuropsychological parameters except Digit Span, Stroop, Clock Draw and JLO.
Similar to AD, functional decline in PD correlates with multiple measures of cognitive impairment. Some differences between PD and AD may be explained by the influence of motor disability and declines in visuospatial function in PD.
背景/目的：此前我们已经表明，帕金森病（PD）和阿尔茨海默病（AD）的功能衰退与认知衰退的整体指标相关。现在我们使用个体认知测量方法来确定PD中认知障碍与功能能力之间的相关性是否与AD中的相似。
93名PD受试者和124名AD/轻度认知障碍（MCI）受试者接受了功能评估分期（FAST）、总体衰退量表（GDS）和一组神经心理学测试。
在PD受试者中，FAST和GDS与雷伊听觉词语学习测验（AVLT）、受控口语词语联想测验（COWA）、动物流畅性测验和斯特鲁普测验显著相关，但与画钟测验或判断线方向测验（JLO）无关。在AD/MCI受试者中，FAST和GDS与除斯特鲁普测验外的所有神经心理学成分相关。在AD/MCI组中，统一帕金森病评定量表（UPDRS）与FAST、GDS、简易精神状态检查表（MMSE）以及除斯特鲁普测验外的所有神经心理学参数显著相关。在PD组中，运动UPDRS与FAST、GDS、MMSE以及除数字广度测验、斯特鲁普测验、画钟测验和JLO外的所有神经心理学参数显著相关。
与AD相似，PD中的功能衰退与多种认知障碍测量指标相关。PD和AD之间的一些差异可能由PD中的运动功能障碍和视觉空间功能衰退的影响来解释。
