Department of Cardiology, Respiratory Medicine and Intensive Care, Klinikum Augsburg, Ludwig-Maximilians-University Munich, Germany.
Thromb Res. 2011 Dec;128(6):e144-7. doi: 10.1016/j.thromres.2011.07.045. Epub 2011 Aug 17.
Although recurrent venous thromboembolism is a known risk factor for chronic thromboembolic pulmonary hypertension (CTEPH), the prevalence of CTEPH after recurrent pulmonary embolism (PE) is not clear.
A cohort screening study was performed to clarify the prevalence of echocardiographic variables indicating pulmonary hypertension (PH) in patients after recurrent PE.
43 survivors of recurrent PE could be enrolled. Echocardiography indicated likely PH in 7 patients. In 5 out of these 7 patients PH was likely and the left ventricular function was normal. Right heart catheterization and ventilation/perfusion lung scan were performed in these patients. CTEPH could be diagnosed in all 5 patients (11.6% of the total study population). No World Health Organisation functional class (WHO-FC) I patient was suspected to have CTEPH. CTEPH was significantly more often diagnosed in WHO-FC III than in WHO-FC II (33.3% versus 9.5%; p=0.024).
CTEPH was found to be a frequent sequela in patients with recurrent PE. The prevalence of CTEPH is dependent on the patient's functional class. Evaluation for PH might be useful in symptomatic patients after recurrent PE.
虽然复发性静脉血栓栓塞是慢性血栓栓塞性肺动脉高压（CTEPH）的已知危险因素，但复发性肺栓塞（PE）后 CTEPH 的患病率尚不清楚。
进行了一项队列筛查研究，以明确复发性 PE 后患者超声心动图变量提示肺动脉高压（PH）的患病率。
可纳入 43 例复发性 PE 幸存者。7 例患者的超声心动图提示可能存在 PH。在这 7 例患者中，有 5 例 PH 很可能且左心室功能正常。对这些患者进行了右心导管检查和通气/灌注肺扫描。5 例患者均诊断为 CTEPH（占总研究人群的 11.6%）。无一例世界卫生组织功能分级（WHO-FC）I 患者被怀疑患有 CTEPH。CTEPH 在 WHO-FC III 中比在 WHO-FC II 中更常见（33.3%比 9.5%；p=0.024）。
在复发性 PE 患者中，CTEPH 被发现是一种常见的后遗症。CTEPH 的患病率取决于患者的功能分级。对复发性 PE 后有症状的患者进行 PH 评估可能有用。
