Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51 000 Rijeka, Croatia.
Trends Mol Med. 2011 Nov;17(11):677-85. doi: 10.1016/j.molmed.2011.07.003. Epub 2011 Aug 17.
The infection of mice with mouse cytomegalovirus (MCMV) as a model of human cytomegalovirus (HCMV) infection has been particularly informative in elucidating the role of innate and adaptive immune response mechanisms during infection. Millions of years of co-evolution between cytomegaloviruses (CMV) and their hosts has resulted in numerous attempts to overwhelm each other. CMVs devote many genes to modulating the host natural killer (NK) cell response and NK cells employ many strategies to cope with CMV infection. While focusing on these attack-counterattack measures, this review will discuss several novel mechanisms of immune evasion by MCMV, the role of Ly49 receptors in mediating resistance to MCMV, and the impact of the initial NK cell response on the shaping of adaptive immunity.
用鼠巨细胞病毒（MCMV）感染小鼠作为人类巨细胞病毒（HCMV）感染的模型，在阐明感染过程中固有和适应性免疫反应机制的作用方面特别有帮助。巨细胞病毒（CMV）与其宿主之间数百万年的共同进化导致了无数次试图相互压倒的尝试。CMVs 将许多基因用于调节宿主自然杀伤（NK）细胞反应，而 NK 细胞则采用许多策略来应对 CMV 感染。在关注这些攻防措施的同时，本综述将讨论 MCMV 逃避免疫的几种新机制、Ly49 受体在介导对 MCMV 的抗性中的作用，以及初始 NK 细胞反应对适应性免疫的影响。
