在病毒-宿主相互作用中，一切都是公平的：NK 细胞和巨细胞病毒。
All is fair in virus-host interactions: NK cells and cytomegalovirus.
机构信息
Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, B. Branchetta 20, 51 000 Rijeka, Croatia.
出版信息
Trends Mol Med. 2011 Nov;17(11):677-85. doi: 10.1016/j.molmed.2011.07.003. Epub 2011 Aug 17.
Abstract
The infection of mice with mouse cytomegalovirus (MCMV) as a model of human cytomegalovirus (HCMV) infection has been particularly informative in elucidating the role of innate and adaptive immune response mechanisms during infection. Millions of years of co-evolution between cytomegaloviruses (CMV) and their hosts has resulted in numerous attempts to overwhelm each other. CMVs devote many genes to modulating the host natural killer (NK) cell response and NK cells employ many strategies to cope with CMV infection. While focusing on these attack-counterattack measures, this review will discuss several novel mechanisms of immune evasion by MCMV, the role of Ly49 receptors in mediating resistance to MCMV, and the impact of the initial NK cell response on the shaping of adaptive immunity.
摘要
用鼠巨细胞病毒（MCMV）感染小鼠作为人类巨细胞病毒（HCMV）感染的模型，在阐明感染过程中固有和适应性免疫反应机制的作用方面特别有帮助。巨细胞病毒（CMV）与其宿主之间数百万年的共同进化导致了无数次试图相互压倒的尝试。CMVs 将许多基因用于调节宿主自然杀伤（NK）细胞反应，而 NK 细胞则采用许多策略来应对 CMV 感染。在关注这些攻防措施的同时，本综述将讨论 MCMV 逃避免疫的几种新机制、Ly49 受体在介导对 MCMV 的抗性中的作用，以及初始 NK 细胞反应对适应性免疫的影响。
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本文引用的文献
1
Natural killer cell memory.自然杀伤细胞记忆。
Nat Immunol. 2011 Jun;12(6):500-8. doi: 10.1038/ni.2032.
2
Distinct MHC class I-dependent NK cell-activating receptors control cytomegalovirus infection in different mouse strains.不同 MHC I 类依赖性 NK 细胞激活受体控制不同小鼠品系的巨细胞病毒感染。
J Exp Med. 2011 May 9;208(5):1105-17. doi: 10.1084/jem.20101831. Epub 2011 Apr 25.
3
Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC.在免疫重建和激活过程中，MHC 独立地控制着 Ly49G2+ NK 细胞主导的早期反应。
Blood. 2011 Jun 30;117(26):7032-41. doi: 10.1182/blood-2010-11-316653. Epub 2011 Apr 15.
4
Self MHC class I-licensed NK cells enhance adaptive CD8 T-cell viral immunity.自体 MHC I 类分子许可的 NK 细胞增强适应性 CD8 T 细胞的病毒免疫。
Blood. 2011 May 12;117(19):5133-41. doi: 10.1182/blood-2010-12-324632. Epub 2011 Mar 23.
5
NK cells and immune "memory".自然杀伤细胞与免疫“记忆”。
J Immunol. 2011 Feb 15;186(4):1891-7. doi: 10.4049/jimmunol.1003035.
6
Homeostatic proliferation generates long-lived natural killer cells that respond against viral infection.稳态增殖产生了对抗病毒感染的长寿命自然杀伤细胞。
J Exp Med. 2011 Feb 14;208(2):357-68. doi: 10.1084/jem.20100479. Epub 2011 Jan 24.
7
Innate or adaptive immunity? The example of natural killer cells.先天免疫还是适应性免疫？以自然杀伤细胞为例。
Science. 2011 Jan 7;331(6013):44-9. doi: 10.1126/science.1198687.
8
Functional consequences of natural sequence variation of murine cytomegalovirus m157 for Ly49 receptor specificity and NK cell activation.天然存在于鼠巨细胞病毒 m157 中的序列变异对 Ly49 受体特异性和 NK 细胞激活的功能影响。
J Immunol. 2011 Feb 1;186(3):1713-22. doi: 10.4049/jimmunol.1003308. Epub 2010 Dec 27.
9
The function of natural killer cells: education, reminders and some good memories.自然杀伤细胞的功能：教育、提醒和一些美好回忆。
Curr Opin Immunol. 2011 Apr;23(2):228-33. doi: 10.1016/j.coi.2010.11.008. Epub 2010 Dec 13.
10
Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T cell accrual.浆细胞样树突状细胞消融会影响早期干扰素反应和抗病毒 NK 及 CD8(+)T 细胞的积累。
Immunity. 2010 Dec 14;33(6):955-66. doi: 10.1016/j.immuni.2010.11.020. Epub 2010 Dec 2.
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