University of Miami Miller School of Medicine, Miami VAHS GRECC, Florida, USA.
J Gerontol A Biol Sci Med Sci. 2011 Nov;66(11):1211-7. doi: 10.1093/gerona/glr114. Epub 2011 Aug 17.
Longevity clusters in families, and parental longevity may be associated with lower risk of chronic diseases in their children. It is unknown if diabetes risk is associated with parental longevity.
We evaluated participants in the Diabetes Prevention Program with a parental history questionnaire at study entry. We classified them into five groups: premature death (parental death at age < 50 years), parental longevity (living to at least 80 years), and three intermediate groups (alive by age 49 but dying at age 50-59, 60-69, or 70-79). Those with alive parents and younger than 80 years were excluded. We analyzed separately effects of paternal (n = 2,165) and maternal (n = 1,739) longevity on diabetes incidence and risk after an average follow-up of 3.2 years.
At baseline, more diabetes risk factors (parental history of diabetes, coronary heart disease, higher body mass index, homeostasis model assessment for insulin resistance, and corrected insulin response) were found in participants whose parents died prematurely. Diabetes incidence was 9.5 cases/100 person-years in the 229 whose fathers died prematurely. In the 618 with paternal longevity, the rate was 6.6 cases/100 person-years (hazard ratio [95% confidence interval] = 0.68 [0.49-0.94]). The rates were 10.7 cases/100 person-years (n = 156) and 7.3 cases/100 person-years (n = 699, hazard ratio = 0.67 [95% confidence interval 0.47-0.95]) for those with maternal premature death or longevity, respectively. Associations with demographic and diabetes risk factors had minimal influence on the reduced risk found in those with paternal (adjusted hazard ratio = 0.78, 95% confidence interval 0.52-1.16) and maternal (adjusted hazard ratio = 0.64, 95% confidence interval 0.41-1.01) longevity.
Parental longevity is associated with lower diabetes incidence in adults at high risk of type 2 diabetes.
长寿家族中，父母的长寿可能与子女患慢性病的风险较低有关。目前尚不清楚糖尿病风险是否与父母的长寿有关。
我们在研究开始时，用父母病史问卷评估了糖尿病预防计划的参与者。我们将他们分为五组：早逝（父母在 50 岁前去世）、父母长寿（至少活到 80 岁），以及三个中间组（父母在 49 岁前还活着，但在 50-59 岁、60-69 岁或 70-79 岁去世）。排除那些父母健在且年龄小于 80 岁的参与者。我们分别分析了父亲（n=2165）和母亲（n=1739）长寿对平均随访 3.2 年后糖尿病发病率和风险的影响。
在基线时，父母早逝的参与者有更多的糖尿病危险因素（父母糖尿病史、冠心病、更高的体重指数、胰岛素抵抗评估的稳态模型和校正后的胰岛素反应）。229 名父亲早逝的参与者中，糖尿病的发病率为 9.5 例/100 人年。在 618 名父亲长寿的参与者中，发病率为 6.6 例/100 人年（风险比[95%置信区间]为 0.68[0.49-0.94]）。那些母亲早逝或长寿的参与者的发病率分别为 10.7 例/100 人年（n=156）和 7.3 例/100 人年（n=699，风险比=0.67[95%置信区间 0.47-0.95]）。与人口统计学和糖尿病危险因素的关联对父亲（校正风险比=0.78，95%置信区间 0.52-1.16）和母亲（校正风险比=0.64，95%置信区间 0.41-1.01）长寿者的风险降低影响不大。
在 2 型糖尿病高危成年人中，父母长寿与较低的糖尿病发病率有关。
