Department of Clinical Pharmacology and Therapeutics, Japan.
J Hypertens. 2010 Feb;28(2):272-7. doi: 10.1097/HJH.0b013e328332fa78.
Longevity is clustered in particular families. Some studies using conventional blood pressure (BP) reported an association between parental longevity and offspring's BP. No study has used self-measurement of BP at home (home BP). We examined the association between parental longevity and home BP values of adult Japanese offspring.
Home and conventional BPs were measured in 1961 residents aged 40 years and over in the general population of Ohasama, Japan. Information about the ages of offspring's parents (age at death or current age) was obtained from a standardized questionnaire.
The mean +/- SD values of systolic/diastolic home BP in offspring whose mothers died at less than 69 years of age, at 69-84 years of age, and in offspring whose mothers were alive at age 84 years were 127.4 +/- 13.2/76.2 +/- 9.1, 124.8 +/- 15.0/74.4 +/- 10.0, and 123.4 +/- 15.2/74.4 +/- 10.3 mmHg (P = 0.0002/0.009), respectively. Corresponding values in offspring whose fathers died at less than 66 years of age, at 66-80 years of age, and in offspring whose fathers were alive at age 80 years were 125.7 +/- 15.2/75.6 +/- 10.6, 124.7 +/- 14.1/75.0 +/- 9.2 and 122.4 +/- 14.6/73.6 +/- 9.5 mmHg (P = 0.001/0.003), respectively. Multivariate analysis demonstrated associations that were only weakly observed for conventional BP values (conventional BP: P = 0.3/0.4 for maternal and P = 0.3/0.3 for paternal longevity; home BP: P = 0.05/0.2 for maternal and P = 0.0004/0.007 for paternal longevity).
Parental premature death was significantly associated with higher home BP levels in adult offspring, suggesting that parental longevity might be a useful additional marker for screening adult offspring at higher risk of hypertension.
长寿具有家族聚集性。一些使用常规血压（BP）的研究报告称，父母的长寿与子女的 BP 之间存在关联。尚无研究使用家庭自测血压（家庭 BP）。我们研究了父母的长寿与日本成年子女家庭 BP 值之间的关系。
在日本大相模市的一般人群中，对年龄在 40 岁及以上的 1961 名居民进行了家庭和常规 BP 测量。从标准化问卷中获得了有关子女父母年龄（死亡年龄或当前年龄）的信息。
母亲在 69 岁以下、69-84 岁和 84 岁时去世的子女的家庭收缩压/舒张压的平均值（+/- SD）分别为 127.4 +/- 13.2/76.2 +/- 9.1、124.8 +/- 15.0/74.4 +/- 10.0 和 123.4 +/- 15.2/74.4 +/- 10.3 mmHg（P = 0.0002/0.009）。父亲在 66 岁以下、66-80 岁和 80 岁时去世的子女的家庭收缩压/舒张压的对应值分别为 125.7 +/- 15.2/75.6 +/- 10.6、124.7 +/- 14.1/75.0 +/- 9.2 和 122.4 +/- 14.6/73.6 +/- 9.5 mmHg（P = 0.001/0.003）。多变量分析显示，仅在常规 BP 值方面观察到弱关联（常规 BP：母亲长寿的 P = 0.3/0.4，父亲长寿的 P = 0.3/0.3；家庭 BP：母亲长寿的 P = 0.05/0.2，父亲长寿的 P = 0.0004/0.007）。
父母的早逝与成年子女的家庭 BP 水平升高显著相关，提示父母的长寿可能是筛查高血压风险较高的成年子女的有用附加标志物。
