Cancer. Aneuploidy drives a mutator phenotype in cancer.
作者信息
Kolodner Richard D, Cleveland Don W, Putnam Christopher D
机构信息
Ludwig Institute for Cancer Research, University of California San Diego School of Medicine, La Jolla, CA 92093-0660, USA.
出版信息
Science. 2011 Aug 19;333(6045):942-3. doi: 10.1126/science.1211154.
Abstract
摘要
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Identification of aneuploidy-tolerating mutations.非整倍体耐受性突变的鉴定。
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DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice.DNA 聚合酶 ε 和 δ 的校对功能抑制了小鼠离散突变体和癌症表型。
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Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells.非整倍体影响哺乳动物细胞的增殖和自发永生化。
Science. 2008 Oct 31;322(5902):703-9. doi: 10.1126/science.1160058.
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A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy.有丝分裂癌症基因普查：对肿瘤细胞生物学和癌症治疗的新见解。
Carcinogenesis. 2007 May;28(5):899-912. doi: 10.1093/carcin/bgm019. Epub 2007 Jan 27.
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