Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Nat Rev Immunol. 2011 Aug 19;11(9):575-83. doi: 10.1038/nri3046.
Animal models and human in vitro systems indicate that dendritic cells (DCs) have a crucial role in priming naive T cells, but just how important are they in the intact human? Recent descriptions of human DC deficiency have begun to shed light on this question and to illuminate other puzzles of human DC biology, including their haematopoietic origin, developmental regulation and homeostatic equilibrium with other leukocytes. In this Review, we explore the recently described DC deficiency syndromes, discussing what these have taught us with regard to DC function in humans and the important issues that remain unsolved.
动物模型和人类体外系统表明树突状细胞 (DC) 在激活初始 T 细胞方面起着至关重要的作用，但它们在完整的人体中究竟有多重要？最近对人类 DC 缺乏症的描述开始揭示这个问题，并阐明了人类 DC 生物学的其他难题，包括其造血起源、发育调控以及与其他白细胞的稳态平衡。在这篇综述中，我们探讨了最近描述的 DC 缺乏综合征，讨论了这些疾病对我们了解人类 DC 功能以及仍未解决的重要问题所带来的启示。
