Zhang Che, Gu Jiaowei, Cheng Xiaoli, Xiong Kui
Taihe Hospital affiliated to Hubei Medical University, No, 32 South People's Road, Shiyan, Hubei Province, 442000, P,R,China.
J Med Case Rep. 2011 Aug 19;5:394. doi: 10.1186/1752-1947-5-394.
Tumoral calcinosis is a rare and benign condition characterized by massive subcutaneous soft tissue deposits of calcium phosphate predominantly around large joints.
Familial tumoral calcinosis was present in two members of a Han Chinese family, namely, the son and daughter. The 14-year-old son had the first operation on his right sole of the foot at the age of six, and then experienced subsequent surgeries at a lesion in his right sole of the foot and left hip, respectively. The 16-year-old daughter underwent her first operation at the age of six in her left gluteal region, and subsequent surgeries were performed due to recurrence at the same lesion. Pathologic diagnoses of surgical specimens in both of the patients were reported as tumoral calcinosis. The laboratory results showed hyperphosphatemia with normal levels of serum calcium and alkaline phosphatase. Only surgical treatment was performed in both patients with satisfactory prognosis.
This is the first report of Chinese familial tumoral calcinosis. The etiopathogenisis and treatment are discussed.
肿瘤性钙化是一种罕见的良性疾病，其特征是磷酸钙在大关节周围大量沉积于皮下软组织。
一个汉族家庭的两名成员，即儿子和女儿，患有家族性肿瘤性钙化。14岁的儿子6岁时首次在右脚足底接受手术，随后分别在右脚足底和左髋部的病变处接受了后续手术。16岁的女儿6岁时首次在左臀区域接受手术，由于同一病变复发而进行了后续手术。两名患者手术标本的病理诊断均报告为肿瘤性钙化。实验室结果显示血磷升高，血清钙和碱性磷酸酶水平正常。两名患者均仅接受了手术治疗，预后良好。
这是中国家族性肿瘤性钙化的首例报告。对其病因和治疗进行了讨论。
